INT314053

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.20
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (VEGFA, Mmp2) extracellular space (VEGFA, Mmp2) extracellular region (VEGFA, Mmp2)
proteinaceous extracellular matrix (VEGFA, Mmp2) peptidase activity (Mmp2) growth (VEGFA)
Anatomy Link Frequency
endothelial cells 4
VEGFA (Homo sapiens)
Mmp2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 62 100.00 Very High Very High Very High
Potency 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 314 74.04 Quite High
Breast Cancer 18 52.60 Quite High
Metastasis 66 50.00 Quite Low
Recurrence 2 28.52 Quite Low
Severe Combined Immunodeficiency 18 5.00 Very Low Very Low Very Low
Colon Cancer 16 5.00 Very Low Very Low Very Low
Hypoxia 14 5.00 Very Low Very Low Very Low
Injury 14 5.00 Very Low Very Low Very Low
Apoptosis 14 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VEGF is known to be able to induce MMP-2 expression in endothelial cells [62].
VEGF Positive_regulation (induce) of Gene_expression (expression) of MMP-2 in endothelial cells associated with metalloproteinase
1) Confidence 0.02 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2880989 Disease Relevance 0.13 Pain Relevance 0.24
We thus tested whether THL could inhibit VEGF-induced MMP-2 expression in endothelial cells.
VEGF Spec (whether) Positive_regulation (induced) of Gene_expression (expression) of MMP-2 in endothelial cells associated with metalloproteinase
2) Confidence 0.01 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2880989 Disease Relevance 0.07 Pain Relevance 0.23

General Comments

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