INT314069

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.95
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Gopc, Stat1) transport (Gopc) Golgi apparatus (Gopc)
enzyme binding (Stat1) DNA binding (Stat1) nucleolus (Stat1)
Anatomy Link Frequency
macrophages 3
Gopc (Mus musculus)
Stat1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 84 85.40 High High
chemokine 9 77.08 Quite High
Inflammatory mediators 3 50.76 Quite High
cytokine 33 46.80 Quite Low
agonist 3 32.64 Quite Low
Crohn's disease 12 5.00 Very Low Very Low Very Low
Piles 6 5.00 Very Low Very Low Very Low
aspirin 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 114 86.28 High High
Disease 45 85.76 High High
INFLAMMATION 81 85.40 High High
Colitis 57 35.52 Quite Low
Body Weight 15 5.00 Very Low Very Low Very Low
Cancer 15 5.00 Very Low Very Low Very Low
Hemorrhage 15 5.00 Very Low Very Low Very Low
Toxicity 6 5.00 Very Low Very Low Very Low
Diarrhoea 6 5.00 Very Low Very Low Very Low
Anorectal Disorders 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, CXCL10, a STAT1 responsive gene [30] was also suppressed by PEO in activated macrophages (Fig 4).
Fig Negative_regulation (suppressed) of STAT1 in macrophages
1) Confidence 0.14 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.39 Pain Relevance 0.07
In macrophages we also observed a novel dose-dependent decrease of activated STAT1 (pSTAT1) in the nucleus by PEO/PEITC (Fig 5).
Fig Negative_regulation (decrease) of STAT1 in macrophages
2) Confidence 0.12 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.28 Pain Relevance 0.04
In macrophages we also observed a novel dose-dependent decrease of activated STAT1 (pSTAT1) in the nucleus by PEO/PEITC (Fig 5).
Fig Negative_regulation (decrease) of pSTAT1 in macrophages
3) Confidence 0.11 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.28 Pain Relevance 0.04

General Comments

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