INT31407

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.38
First Reported 1987
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.07
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 1
erythrocyte 1
HCA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Analgesic 2 99.50 Very High Very High Very High
Morphine 7 99.40 Very High Very High Very High
antagonist 1 97.90 Very High Very High Very High
cva 8 96.80 Very High Very High Very High
nMDA receptor 3 87.28 High High
Pain 7 77.56 Quite High
excitatory amino acid 1 75.80 Quite High
withdrawal 2 74.68 Quite High
Antinociceptive 1 73.88 Quite High
abdominal pain 3 50.00 Quite Low
Disease Link Frequency Relevance Heat
Weight Loss 40 100.00 Very High Very High Very High
Liver Cell Adenoma 23 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 4 97.72 Very High Very High Very High
Body Weight 26 97.12 Very High Very High Very High
Cv General 3 Under Development 8 96.80 Very High Very High Very High
Necrosis 4 95.68 Very High Very High Very High
Overweight 12 82.16 Quite High
Obesity 30 81.20 Quite High
Pain 9 77.56 Quite High
Death 1 55.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The evidence from RCTs suggests that Garcinia extracts/HCA generate weight loss on the short term.
Negative_regulation (loss) of HCA associated with weight loss
1) Confidence 0.38 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC3010674 Disease Relevance 0.86 Pain Relevance 0
Two studies [28, 31] reported a significant reduction in appetite in the HCA group (P < .001), but not with placebo.
Negative_regulation (reduction) of HCA
2) Confidence 0.38 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC3010674 Disease Relevance 0.55 Pain Relevance 0.04
We also show that known NMDA antagonists, including Mg++, D-aminophosphonopentanoate and certain anesthetics, analgesics, and sedative hypnotics block the neurotoxic actions of L-HCA in direct proportion to their efficacy in blocking NMDA neurotoxicity.
Negative_regulation (block) of L-HCA associated with drug induced neurotoxicity, analgesic and antagonist
3) Confidence 0.17 Published 1987 Journal Brain Res. Bull. Section Abstract Doc Link 2891418 Disease Relevance 0.36 Pain Relevance 0.30
On contrast CT, HCA often shows substantial enhancement during the arterial phase, decreasing during the portal phase and gradually becoming iso- or hypodense in the liver on delayed scans.
Negative_regulation (decreasing) of HCA in liver associated with liver cell adenoma
4) Confidence 0.16 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1950307 Disease Relevance 1.14 Pain Relevance 0.20
In vitro inhibition of erythrocyte HCA-I and HCA-II by morphine using the CO(2)-hydratase enzyme gave IC(50) values 4.50 x 10(-5) M (r(2): 0.954) and 9.23 x 10(-5) M (r(2): 0.996), respectively.
Negative_regulation (inhibition) of HCA-I in erythrocyte associated with morphine
5) Confidence 0.12 Published 2007 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18057708 Disease Relevance 0.15 Pain Relevance 0.81

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox