INT314074

Context Info Confidence 0.25 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.21 Pain Relevance 0.03

signal transduction (Cxcl10) extracellular space (Cxcl10) mitochondrion (Peo1) extracellular region (Cxcl10) helicase activity (Peo1)

Anatomy Link Frequency macrophages 1 Peo1 (Mus musculus) Cxcl10 (Mus musculus)

Pain Link Frequency Relevance Heat chemokine 3 60.96 Inflammation 28 50.00 cytokine 11 30.68 Crohn's disease 4 5.00 Piles 2 5.00 aspirin 1 5.00 cINOD 1 5.00 Bioavailability 1 5.00 Inflammatory mediators 1 5.00 agonist 1 5.00

Disease Link Frequency Relevance Heat Inflammatory Bowel Disease 38 95.56 INFLAMMATION 27 50.00 Colitis 19 43.44 Disease 15 42.80 Body Weight 5 5.00 Cancer 5 5.00 Hemorrhage 5 5.00 Toxicity 2 5.00 Diarrhoea 2 5.00 Anorectal Disorders 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The inhibition of pSTAT1 by PEO is also consistent with our current and previous findings that CXCL10 and iNOS [19] mRNA are down regulated by PEO in activated macrophages.

PEO Regulation (regulated) of CXCL10 in macrophages

1) Confidence 0.25 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.21 Pain Relevance 0.03

General Comments

This test has worked.