INT314078

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Context Info
Confidence 0.31
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.23
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Peo1) nucleolus (Stat1) nucleus (Stat1)
helicase activity (Peo1) enzyme binding (Stat1) DNA binding (Stat1)
Anatomy Link Frequency
macrophages 2
Peo1 (Mus musculus)
Stat1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 112 85.40 High High
chemokine 12 64.60 Quite High
Inflammatory mediators 4 50.76 Quite High
cytokine 44 34.32 Quite Low
agonist 4 32.64 Quite Low
Crohn's disease 16 5.00 Very Low Very Low Very Low
Piles 8 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 152 99.20 Very High Very High Very High
Disease 60 85.76 High High
INFLAMMATION 108 85.40 High High
Colitis 76 52.00 Quite High
Body Weight 20 5.00 Very Low Very Low Very Low
Cancer 20 5.00 Very Low Very Low Very Low
Hemorrhage 20 5.00 Very Low Very Low Very Low
Toxicity 8 5.00 Very Low Very Low Very Low
Diarrhoea 8 5.00 Very Low Very Low Very Low
Anorectal Disorders 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously reported suppression of another STAT1 responsive gene, iNOS by PEO [19].
PEO Negative_regulation (suppression) of STAT1
1) Confidence 0.31 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.32 Pain Relevance 0.04
Additionally, CXCL10, a STAT1 responsive gene [30] was also suppressed by PEO in activated macrophages (Fig 4).
PEO Negative_regulation (suppressed) of STAT1 in macrophages
2) Confidence 0.31 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.39 Pain Relevance 0.07
The inhibition of pSTAT1 by PEO is also consistent with our current and previous findings that CXCL10 and iNOS [19] mRNA are down regulated by PEO in activated macrophages.
PEO Negative_regulation (inhibition) of pSTAT1 in macrophages
3) Confidence 0.30 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.22 Pain Relevance 0.03
Since STAT1 regulates iNOS [38] and CXCL10 [30,41], suppression of pSTAT1 by PEO likely contributes to the downstream inhibition of iNOS and CXCL10.
PEO Negative_regulation (suppression) of pSTAT1
4) Confidence 0.26 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.30 Pain Relevance 0.03

General Comments

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