INT314078
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
We previously reported suppression of another STAT1 responsive gene, iNOS by PEO [19]. | |||||||||||||||
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Additionally, CXCL10, a STAT1 responsive gene [30] was also suppressed by PEO in activated macrophages (Fig 4). | |||||||||||||||
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The inhibition of pSTAT1 by PEO is also consistent with our current and previous findings that CXCL10 and iNOS [19] mRNA are down regulated by PEO in activated macrophages. | |||||||||||||||
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Since STAT1 regulates iNOS [38] and CXCL10 [30,41], suppression of pSTAT1 by PEO likely contributes to the downstream inhibition of iNOS and CXCL10. | |||||||||||||||
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General Comments
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