INT314078

Context Info Confidence 0.31 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 1.23 Pain Relevance 0.17

mitochondrion (Peo1) nucleolus (Stat1) nucleus (Stat1) helicase activity (Peo1) enzyme binding (Stat1) DNA binding (Stat1)

Anatomy Link Frequency macrophages 2 Peo1 (Mus musculus) Stat1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 112 85.40 chemokine 12 64.60 Inflammatory mediators 4 50.76 cytokine 44 34.32 agonist 4 32.64 Crohn's disease 16 5.00 Piles 8 5.00 aspirin 4 5.00 cINOD 4 5.00 Bioavailability 4 5.00

Disease Link Frequency Relevance Heat Inflammatory Bowel Disease 152 99.20 Disease 60 85.76 INFLAMMATION 108 85.40 Colitis 76 52.00 Body Weight 20 5.00 Cancer 20 5.00 Hemorrhage 20 5.00 Toxicity 8 5.00 Diarrhoea 8 5.00 Anorectal Disorders 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We previously reported suppression of another STAT1 responsive gene, iNOS by PEO [19].

PEO Negative_regulation (suppression) of STAT1

1) Confidence 0.31 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.32 Pain Relevance 0.04

Additionally, CXCL10, a STAT1 responsive gene [30] was also suppressed by PEO in activated macrophages (Fig 4).

PEO Negative_regulation (suppressed) of STAT1 in macrophages

2) Confidence 0.31 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.39 Pain Relevance 0.07

The inhibition of pSTAT1 by PEO is also consistent with our current and previous findings that CXCL10 and iNOS [19] mRNA are down regulated by PEO in activated macrophages.

PEO Negative_regulation (inhibition) of pSTAT1 in macrophages

3) Confidence 0.30 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.22 Pain Relevance 0.03

Since STAT1 regulates iNOS [38] and CXCL10 [30,41], suppression of pSTAT1 by PEO likely contributes to the downstream inhibition of iNOS and CXCL10.

PEO Negative_regulation (suppression) of pSTAT1

4) Confidence 0.26 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.30 Pain Relevance 0.03

General Comments

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