INT31408

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Context Info
Confidence 0.28
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.40
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
cleavage 1
brain 1
HCA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
excitatory amino acid 1 99.20 Very High Very High Very High
nMDA receptor 3 93.44 High High
antagonist 1 69.60 Quite High
Pain 5 67.00 Quite High
Analgesic 1 63.12 Quite High
imagery 5 62.12 Quite High
abdominal pain 3 50.00 Quite Low
cINOD 3 45.84 Quite Low
cva 8 22.40 Low Low
isoflurane 1 11.76 Low Low
Disease Link Frequency Relevance Heat
Liver Cell Adenoma 23 100.00 Very High Very High Very High
Malignant Neoplastic Disease 1 99.98 Very High Very High Very High
Cancer 12 79.88 Quite High
Rupture 8 79.32 Quite High
Body Weight 18 76.72 Quite High
Drug Induced Neurotoxicity 4 73.12 Quite High
Hemorrhage 6 72.32 Quite High
Pain 7 67.00 Quite High
Fatigue 1 60.44 Quite High
Contact Dermatitis 2 54.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, we considered that this diagnostic hypothesis should be confirmed by means of a biopsy, since, although the risk of malignant transformation of an HCA is fairly low, it may occur, and would be an important indication for a surgical approach.
Localization (transformation) of HCA associated with malignant neoplastic disease and liver cell adenoma
1) Confidence 0.28 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1950307 Disease Relevance 0.78 Pain Relevance 0.10
L-Homocysteic acid (L-HCA) has been proposed as a natural transmitter at the N-methyl-D-aspartate (NMDA) subtype of excitatory amino acid receptor based on recent evidence that L-HCA occurs L-HCA occurs naturally in the mammalian CNS, is released from K+ stimulated brain slices in a calcium-dependent manner and may be contained in nerve terminals located in certain brain regions that have a high density of NMDA receptors.
Localization (released) of L-HCA in brain associated with nmda receptor and excitatory amino acid
2) Confidence 0.28 Published 1987 Journal Brain Res. Bull. Section Abstract Doc Link 2891418 Disease Relevance 0.13 Pain Relevance 0.23
Since the lactone form has shown to be a very less effective inhibitor of the citrate cleavage enzyme [13], different preparations attempt to prevent cyclization of HCA into its (ineffective) lactone by using different counter-ions (such as sodium, calcium or potassium).
Localization (cyclization) of HCA in cleavage
3) Confidence 0.21 Published 2005 Journal Nutr Metab (Lond) Section Body Doc Link PMC1242253 Disease Relevance 0.38 Pain Relevance 0
HCA was classified as a contact sensitizer serving as a positive control in the LLNA and tested in other in vitro sensitizations tests [15], [38].
Localization (sensitizations) of HCA
4) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.11 Pain Relevance 0

General Comments

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