INT31412

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Context Info
Confidence 0.40
First Reported 1987
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 7.14
Pain Relevance 2.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
plasma 4
skeletal muscle 2
face 2
motor neuron 2
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 7 99.84 Very High Very High Very High
qutenza 11 99.72 Very High Very High Very High
Cholecystokinin 3 99.48 Very High Very High Very High
peripheral neuropathy 1 97.34 Very High Very High Very High
agonist 14 97.00 Very High Very High Very High
Hyperalgesia 2 95.76 Very High Very High Very High
hypoalgesia 6 93.52 High High
tolerance 48 89.52 High High
diabetic neuropathy 2 75.00 Quite High
Chronic pancreatitis 1 73.04 Quite High
Disease Link Frequency Relevance Heat
Insulin Resistance 64 100.00 Very High Very High Very High
Hyperinsulinism 29 100.00 Very High Very High Very High
Diabetes Mellitus 72 98.92 Very High Very High Very High
Obesity 209 98.16 Very High Very High Very High
Stress 8 98.04 Very High Very High Very High
Peripheral Neuropathy 3 97.34 Very High Very High Very High
Vasculitis 1 97.28 Very High Very High Very High
Hyperalgesia 2 95.76 Very High Very High Very High
Acromegaly 36 93.96 High High
Hypoalagesia 6 93.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma norepinephrine and epinephrine levels did not differ between Cap- and Veh-treated animals, whereas the increase in plasma insulin levels normally induced by alpha-adrenoceptor blockade by phentolamine was absent after Cap treatment.
Negative_regulation (absent) of Positive_regulation (increase) of insulin in plasma associated with qutenza
1) Confidence 0.40 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7943418 Disease Relevance 0.24 Pain Relevance 1.01
Moreover, this UAG-induced increase in insulin levels was abolished by the coadministration of AG.
Negative_regulation (abolished) of Positive_regulation (increase) of insulin
2) Confidence 0.36 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.06 Pain Relevance 0
Pioglitazone abolished the CCK-8-evoked hyperinsulinemia (P < 0.005) and increased insulin sensitivity of eNOS(-/-) mice (P < 0.05), the latter based on hyperinsulinemic-euglycemic clamp studies.
Negative_regulation (abolished) of Positive_regulation (increased) of insulin associated with hyperinsulinism
3) Confidence 0.33 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17510194 Disease Relevance 0.66 Pain Relevance 0.13
GhrR KO mice, therefore, have increased insulin sensitivity characterized by a decreased insulin requirement for glucose disposal relative to WT controls.
Negative_regulation (decreased) of Positive_regulation (requirement) of insulin associated with hyperinsulinism
4) Confidence 0.27 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.91 Pain Relevance 0
This insulin sensitivity is characterized by a decreased insulin requirement in the face of a glucose challenge.
Negative_regulation (decreased) of Positive_regulation (requirement) of insulin in face
5) Confidence 0.20 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.29 Pain Relevance 0
This functional defect is partly due to a decrease in insulin-stimulated Akt activation and failure in the translocation of glucose transporter GLUT4 to the cell surface [11], [12], [13].
Negative_regulation (decrease) of Positive_regulation (activation) of insulin
6) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.77 Pain Relevance 0.11
However, GH also potentiates insulin release which is reflected in the high prevalence of high insulin levels both at rest and after glucose challenge (Cerasi and Luft 1964).
Negative_regulation (reflected) of Positive_regulation (prevalence) of insulin associated with hyperinsulinism
7) Confidence 0.09 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 1.20 Pain Relevance 0.26
The elevated plasma insulin levels after injection of carbachol or terbutaline were lowered by clonidine but not by phenylephrine whereas the CCK-8-induced increase in plasma insulin levels was not affected by either clonidine or phenylephrine.
Neg (not) Negative_regulation (lowered) of Positive_regulation (elevated) of insulin in plasma associated with clonidine
8) Confidence 0.09 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2891547 Disease Relevance 0 Pain Relevance 0.74
Another potential cause of reduced insulin sensitivity through RAS activation may be a result of vasoconstrictive effects, thereby reducing blood flow to skeletal muscle (Furuhashi et al 2003).
Negative_regulation (reduced) of Positive_regulation (activation) of insulin in skeletal muscle
9) Confidence 0.07 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 1.07 Pain Relevance 0.03
Peripheral neuropathy is a particularly debilitating complication of both type 1 and type 2 diabetes characterized by sensory and motor neuron damage and decreased circulating levels of insulin-like growth factor 1 (IGF-1).
Negative_regulation (decreased) of Positive_regulation (circulating) of insulin in motor neuron associated with diabetes mellitus and peripheral neuropathy
10) Confidence 0.06 Published 2008 Journal Mol. Ther. Section Abstract Doc Link 18545223 Disease Relevance 0.90 Pain Relevance 0.55
Such treatment has been shown to inhibit insulin receptor substrate -1 (IRS-1) expression [60] and activation [61] thereby inducing insulin resistance.
Negative_regulation (inhibit) of Positive_regulation (inducing) of insulin associated with insulin resistance
11) Confidence 0.01 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2441623 Disease Relevance 1.04 Pain Relevance 0

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