INT314131

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Context Info
Confidence 0.67
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.56
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Prdm16) nucleus (Prdm16) intracellular (Prdm16)
DNA binding (Prdm16)
Anatomy Link Frequency
brown fat cell 1
finger 1
Prdm16 (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 7 60.52 Quite High
Bile 7 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 119 97.92 Very High Very High Very High
Neutrophil Disorders 1 94.16 High High
Cancer 8 88.44 High High
Sepsis 1 86.88 High High
Genetic Translocation 1 85.80 High High
Targeted Disruption 55 82.08 Quite High
Congenital Anomalies 3 81.96 Quite High
Disease 11 80.28 Quite High
Leukemia 2 77.36 Quite High
Severe Combined Immunodeficiency 2 64.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this sense, an increase in the gene expression levels of the recently identified transcription factor PRDM16, a positive transcriptional regulator of the brown fat cell gene program [10] was observed in iNOS-deficient mice.
Positive_regulation (increase) of PRDM16 in brown fat cell associated with obesity
1) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 0.84 Pain Relevance 0.06
Vector integrations activated the zinc finger transcription factor homolog's MDS1/EVI1, PRDM16 or SETBP1 raising concerns that this could eventually cause tumourgenesis.
Positive_regulation (activated) of PRDM16 in finger
2) Confidence 0.18 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.72 Pain Relevance 0

General Comments

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