INT314136

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.78
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TAC1, SFTPA1) extracellular region (TAC1, SFTPA1) plasma membrane (TAC1)
cell-cell signaling (TAC1)
Anatomy Link Frequency
skin 1
TAC1 (Homo sapiens)
SFTPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 67 100.00 Very High Very High Very High
pruritus 71 96.56 Very High Very High Very High
Central nervous system 5 95.44 Very High Very High Very High
Spinal cord 1 92.64 High High
Opioid 1 80.84 Quite High
Potency 3 80.56 Quite High
antagonist 32 77.04 Quite High
Pain 12 67.76 Quite High
cytokine 15 64.80 Quite High
antidepressant 2 62.24 Quite High
Disease Link Frequency Relevance Heat
Pruritus 82 96.56 Very High Very High Very High
Disease 8 70.44 Quite High
Pain 12 67.76 Quite High
Lung Cancer 2 65.68 Quite High
Suicidal Behaviour 1 36.68 Quite Low
Depression 3 36.04 Quite Low
Injury 1 32.44 Quite Low
Chronic Renal Failure 4 10.48 Low Low
Uremia 3 8.56 Low Low
INFLAMMATION 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to TAC4, we have shown that TAC1, which encodes for SP and NKA, was not detected under our experimental conditions and that TAC3 was observed in only one of four samples.
TAC1 Binding (encodes) of SP associated with substance p
1) Confidence 0.03 Published 2010 Journal Respir Res Section Body Doc Link PMC2959027 Disease Relevance 0.07 Pain Relevance 0.13
SP is a tachykinin which binds with different affinities to three neurokinin receptors (NKR 1–3), but mainly to NKR1, which is expressed in the central nervous system (CNS) and the skin [11].
tachykinin Binding (binds) of SP in skin associated with central nervous system and substance p
2) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881044 Disease Relevance 0.71 Pain Relevance 0.93

General Comments

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