INT314141

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.02
Pain Relevance 2.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SFTPA1) signal transduction (Tacr3) extracellular region (SFTPA1)
plasma membrane (Tacr3) nucleus (Tacr3) signal transducer activity (Tacr3)
Anatomy Link Frequency
skin 1
keratinocytes 1
mast cells 1
Tacr3 (Mus musculus)
SFTPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 63 100.00 Very High Very High Very High
Central nervous system 15 98.88 Very High Very High Very High
pruritus 213 96.56 Very High Very High Very High
cytokine 3 94.16 High High
Inflammation 12 93.76 High High
Potency 3 87.44 High High
antagonist 36 83.92 Quite High
Opioid 3 80.84 Quite High
Onset of action 3 73.80 Quite High
Pain 36 67.76 Quite High
Disease Link Frequency Relevance Heat
Necrosis 3 97.68 Very High Very High Very High
Cancer 3 97.32 Very High Very High Very High
Pruritus 246 96.56 Very High Very High Very High
INFLAMMATION 12 93.76 High High
Skin Diseases 9 71.44 Quite High
Disease 18 70.44 Quite High
Spontaneous Remission 3 69.60 Quite High
Pain 36 67.76 Quite High
Vomiting 12 52.32 Quite High
Lymphatic System Cancer 3 51.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, prostaglandin D2, and leukotriene B4 via binding of SP to NKR1 on keratinocytes and mast cells [13], [19], [20].
NKR1 Binding (binding) of SP in mast cells associated with substance p
1) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881044 Disease Relevance 1.14 Pain Relevance 0.77
SP is a tachykinin which binds with different affinities to three neurokinin receptors (NKR 1–3), but mainly to NKR1, which is expressed in the central nervous system (CNS) and the skin [11].
NKR1 Binding (binds) of SP in skin associated with central nervous system and substance p
2) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881044 Disease Relevance 0.73 Pain Relevance 0.95
, prostaglandin D2, and leukotriene B4 via binding of SP to NKR1 on keratinocytes and mast cells [13], [19], [20].
NKR1 Binding (binding) of SP in keratinocytes associated with substance p
3) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881044 Disease Relevance 1.14 Pain Relevance 0.77

General Comments

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