INT314186

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.78
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Npm1) nucleoplasm (Npm1) histone binding (Npm1)
enzyme binding (Npm1) DNA binding (Npm1) response to stress (Npm1)
Anatomy Link Frequency
macrophages 1
Npm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 90 93.08 High High
allodynia 78 81.76 Quite High
Pain 34 77.44 Quite High
Inflammatory mediators 16 70.72 Quite High
Painful diabetic neuropathy 54 67.96 Quite High
Trk A 22 57.08 Quite High
Inflammation 30 39.00 Quite Low
COX2 58 31.64 Quite Low
IPN 4 26.80 Quite Low
Neuropathic pain 8 15.20 Low Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 88 99.56 Very High Very High Very High
Hyperglycemia 6 91.92 High High
Neuropathic Pain 96 81.76 Quite High
Pain 30 77.44 Quite High
INFLAMMATION 46 70.32 Quite High
Diabetic Neuropathy 72 67.96 Quite High
Nociception 12 60.24 Quite High
Osteoarthritis 2 33.28 Quite Low
Disease 4 32.60 Quite Low
Inflammatory Pain 4 26.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Levels of pp38 in kidneys increased (2-6 fold) following the onset of diabetes in interstitial macrophages and myofibroblasts of db/db mice in a manner that was associated with increased NGF expression downstream of hyperglycemia, and increased HbA(1)c.
Gene_expression (Levels) of pp38 in macrophages associated with hyperglycemia, nerve growth factor and diabetes mellitus
1) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 1.10 Pain Relevance 0.66
Densitometric studies which normalized the levels of pp38 to that of total p38 and actin revealed significantly increased p38 phosphorylation in the db/db mouse at 5, 8, and 10 wk of age.
Gene_expression (levels) of pp38
2) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.68 Pain Relevance 0.57

General Comments

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