INT314189

Context Info Confidence 0.02 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 2.16 Pain Relevance 1.70

cell differentiation (Nr5a1) lipid binding (Nr5a1) nucleus (Nr5a1) enzyme binding (Nr5a1) DNA binding (Nr5a1)

Anatomy Link Frequency dorsal root 1 neurons 1 Nr5a1 (Mus musculus)

Pain Link Frequency Relevance Heat Nerve growth factor 45 100.00 Trk A 11 100.00 Hyperalgesia 6 99.82 Inflammation 15 95.52 Pain 17 91.24 Spinal cord 6 90.16 Neuropathic pain 4 88.16 Painful diabetic neuropathy 27 74.88 allodynia 39 60.16 tolerance 1 54.04

Disease Link Frequency Relevance Heat Nociception 6 99.84 Hyperalgesia 7 99.82 INFLAMMATION 23 95.52 Pain 15 91.24 Neuropathic Pain 48 88.16 Diabetic Neuropathy 36 74.88 Diabetes Mellitus 44 70.64 Impaired Glucose Tolerance 1 54.04 Disease 2 45.36 Neuropathy 1 36.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In a model of NGF-induced hyperalgesia, p38 is phosphorylated in Trk A-positive small to medium-sized dorsal root ganglian (DRG) neurons and phosphorylated p38 (pp38) mediates NGF-induced upregulation of nociceptive molecules [10].

Positive_regulation (upregulation) of in neurons Phosphorylation (phosphorylated) of A-positive in dorsal root associated with nociception, hyperalgesia, nerve growth factor and trk a

1) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 2.16 Pain Relevance 1.70

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