INT31419

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Context Info
Confidence 0.70
First Reported 1988
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 0.77
Pain Relevance 3.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) extracellular region (Sst)
Anatomy Link Frequency
lumen 4
somatotrope 2
parietal cells 2
stomach 2
Sst (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 107 100.00 Very High Very High Very High
tetrodotoxin 10 99.28 Very High Very High Very High
antagonist 13 94.40 High High
Neurotransmitter 6 93.96 High High
tolerance 5 90.36 High High
Serotonin 1 87.52 High High
opioid receptor 1 84.48 Quite High
Clonidine 1 84.00 Quite High
depression 1 82.12 Quite High
substance P 1 81.24 Quite High
Disease Link Frequency Relevance Heat
Hyperinsulinism 2 100.00 Very High Very High Very High
Impaired Glucose Tolerance 5 90.36 High High
Depression 1 82.12 Quite High
Insulin Resistance 3 79.72 Quite High
Acromegaly 36 76.80 Quite High
Cancer 24 56.48 Quite High
Alopecia 1 46.60 Quite Low
Constipation 1 46.00 Quite Low
Fatigue 1 45.44 Quite Low
Reprotox - General 1 1 44.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is proposed that acid-induced release of somatostatin in proximity to parietal cells serves as a negative feedback mechanism restraining acid secretion.
Positive_regulation (induced) of Localization (release) of somatostatin in parietal cells associated with somatostatin
1) Confidence 0.70 Published 1988 Journal Gastroenterology Section Abstract Doc Link 2891584 Disease Relevance 0 Pain Relevance 0.40
Perfusion of the lumen with exogenous acid (80-480 nmol/min) caused an increase in somatostatin secretion in proportion to the increase in luminal acidity.
Positive_regulation (increase) of Localization (secretion) of somatostatin in lumen associated with somatostatin
2) Confidence 0.70 Published 1988 Journal Gastroenterology Section Abstract Doc Link 2891584 Disease Relevance 0 Pain Relevance 0.38
The increase in somatostatin secretion was resistant to tetrodotoxin and attained maximal levels (61.6% +/- 8.7% above basal level) similar to those elicited by maximal doses of secretagogues.
Positive_regulation (increase) of Localization (secretion) of somatostatin associated with tetrodotoxin and somatostatin
3) Confidence 0.70 Published 1988 Journal Gastroenterology Section Abstract Doc Link 2891584 Disease Relevance 0 Pain Relevance 0.42
The present study was designed to determine whether somatostatin secretion induced by histamine or pentagastrin in the isolated luminally perfused mouse stomach was a direct effect of the secretagogues on gastric somatostatin cells or an indirect effect mediated by the increase in luminal acidity.
Spec (whether) Positive_regulation (induced) of Localization (secretion) of somatostatin in stomach associated with somatostatin
4) Confidence 0.70 Published 1988 Journal Gastroenterology Section Abstract Doc Link 2891584 Disease Relevance 0 Pain Relevance 0.27
Similarly, neutralization of the secretagogue-induced increments in acid secretion with bicarbonate or inhibition of the increments with cimetidine abolished the corresponding increments in somatostatin secretion.
Positive_regulation (increments) of Localization (secretion) of somatostatin associated with somatostatin
5) Confidence 0.50 Published 1988 Journal Gastroenterology Section Abstract Doc Link 2891584 Disease Relevance 0 Pain Relevance 0.40
Perfusion of the lumen with exogenous acid (80-480 nmol/min) caused an increase in somatostatin secretion in proportion to the increase in luminal acidity.
Positive_regulation (caused) of Localization (secretion) of somatostatin in lumen associated with somatostatin
6) Confidence 0.47 Published 1988 Journal Gastroenterology Section Abstract Doc Link 2891584 Disease Relevance 0 Pain Relevance 0.38
Effects of somatostatin analogs on glucose homeostasis are the resultant of delayed intestinal absorption of carbohydrates, inhibition of insulin release and increased insulin sensitivity via diminished GH secretion.
Positive_regulation (increased) of Localization (secretion) of somatostatin associated with somatostatin and hyperinsulinism
7) Confidence 0.24 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.69 Pain Relevance 0.17
Somatostatin release increased during descending relaxation: immunoneutralization of somatostatin or blockade of its effect with a selective somatostatin type 2 receptor antagonist inhibited descending relaxation.
Positive_regulation (increased) of Localization (release) of Somatostatin associated with antagonist and somatostatin
8) Confidence 0.22 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12966154 Disease Relevance 0 Pain Relevance 0.72
Taken together, these data suggest that, at supramaximal caerulein concentrations, galanin acts via its receptors to further increase caerulein-stimulated amylase secretion by inhibiting the caerulein-induced release of somatostatin.
Positive_regulation (increase) of Localization (release) of somatostatin associated with somatostatin
9) Confidence 0.14 Published 2009 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 19779018 Disease Relevance 0 Pain Relevance 0.30
Taken together, these data suggest that, at supramaximal caerulein concentrations, galanin acts via its receptors to further increase caerulein-stimulated amylase secretion by inhibiting the caerulein-induced release of somatostatin.
Positive_regulation (induced) of Localization (release) of somatostatin associated with somatostatin
10) Confidence 0.14 Published 2009 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 19779018 Disease Relevance 0 Pain Relevance 0.29
This effect may be mediated at the hypothalamic level via reduced 5-HT1A receptor function or at the pituitary level, either by a direct effect on somatotrope cells or via enhanced insulin-like growth factor-1 (IGF-1) or somatostatin (SS) release.
Positive_regulation (enhanced) of Localization (release) of SS in somatotrope associated with somatostatin
11) Confidence 0.01 Published 2000 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 11041314 Disease Relevance 0.08 Pain Relevance 0.22

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