INT314203

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.27
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Nos2, Gli3) cytoplasm (Nos2, Gli3) cytosol (Nos2, Gli3)
nucleus (Nos2, Gli3) anatomical structure formation involved in morphogenesis (Gli3) peroxisome (Nos2)
Anatomy Link Frequency
nerve 1
Nos2 (Mus musculus)
Gli3 (Mus musculus)
Pain Link Frequency Relevance Heat
Painful diabetic neuropathy 27 100.00 Very High Very High Very High
allodynia 39 91.24 High High
COX2 29 85.40 High High
Hyperalgesia 6 81.52 Quite High
intrathecal 10 71.04 Quite High
diabetic neuropathy 4 49.68 Quite Low
Inflammation 15 38.36 Quite Low
Nerve growth factor 45 32.52 Quite Low
Pain 17 26.16 Quite Low
substance P 9 24.96 Low Low
Disease Link Frequency Relevance Heat
Diabetic Neuropathy 36 100.00 Very High Very High Very High
Neuropathic Pain 48 99.64 Very High Very High Very High
Diabetes Mellitus 44 97.46 Very High Very High Very High
Targeted Disruption 1 96.60 Very High Very High Very High
Hyperalgesia 7 82.16 Quite High
Renal Disease 1 54.32 Quite High
Diabetes Complications 2 53.40 Quite High
INFLAMMATION 23 38.36 Quite Low
Pain 15 26.16 Quite Low
Nociception 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In agreement with our hypothesis, iNOS knockout mice have increased resistance to diabetic neuropathic complications, including impaired nerve conduction velocities and small fiber sensory neuropathy, indicating that iNOS could be an important mediator of PDN [42].
iNOS Positive_regulation (mediator) of PDN in nerve associated with targeted disruption, painful diabetic neuropathy, diabetes mellitus and neuropathic pain
1) Confidence 0.19 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 1.27 Pain Relevance 0.73

General Comments

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