INT314206

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.67
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Mapk14, Pax3) mitochondrion (Mapk14) cell morphogenesis (Mapk14)
DNA binding (Pax3) response to stress (Mapk14) cytoplasm (Mapk14)
Anatomy Link Frequency
neurons 1
Mapk14 (Mus musculus)
Pax3 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 9 100.00 Very High Very High Very High
Lasting pain 1 95.08 Very High Very High Very High
Dorsal horn 1 94.00 High High
Spinal cord 6 93.52 High High
Nerve growth factor 45 90.48 High High
intrathecal 10 88.72 High High
Trk A 11 88.56 High High
Pain 17 86.68 High High
allodynia 39 76.20 Quite High
Inflammation 15 66.80 Quite High
Disease Link Frequency Relevance Heat
Pain 15 95.08 Very High Very High Very High
Neuropathic Pain 48 76.20 Quite High
INFLAMMATION 23 66.80 Quite High
Diabetes Mellitus 44 63.28 Quite High
Diabetic Neuropathy 36 52.08 Quite High
Hyperalgesia 7 5.00 Very Low Very Low Very Low
Nociception 6 5.00 Very Low Very Low Very Low
Nervous System Injury 3 5.00 Very Low Very Low Very Low
Hyperglycemia 3 5.00 Very Low Very Low Very Low
Diabetes Complications 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The upregulation of SP-positive neurons in our current study is reduced by SB203580, supporting our contention that p38 mediates SP-upregulation in the DRG of db/db mice.
p38 Positive_regulation (mediates) of SP in neurons associated with substance p
1) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.67 Pain Relevance 1.15

General Comments

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