INT314270

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.15
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CPOX) small molecule metabolic process (CPOX) oxidoreductase activity (CPOX)
plasma membrane (PTGER2) signal transducer activity (PTGER2) cytoplasm (CPOX)
Anatomy Link Frequency
PGE2 2
CPOX (Homo sapiens)
PTGER2 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 9 100.00 Very High Very High Very High
Inflammation 30 78.04 Quite High
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
melanocortin 1 receptor 3 5.00 Very Low Very Low Very Low
Immobilon 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dermatitis 3 78.04 Quite High
Erythema 27 68.36 Quite High
Skin Cancer 12 42.72 Quite Low
Malignant Neoplastic Disease 3 25.20 Quite Low
INFLAMMATION 33 5.00 Very Low Very Low Very Low
Burns 15 5.00 Very Low Very Low Very Low
Stress 15 5.00 Very Low Very Low Very Low
Blister 6 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the ability of NS-398 (a selective COX-2 inhibitor) to reduce PGE2 production in some EM cultures clearly suggests a role for this enzyme in this system.
COX Negative_regulation (reduce) of Gene_expression (production) of PGE2 associated with cox-2 inhibitor
1) Confidence 0.01 Published 2010 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2881306 Disease Relevance 0 Pain Relevance 0.05
Epidermal melanocytes expressed cyclooxygenase-2 (COX-2) mRNA and a selective COX-2 inhibitor (NS-398) reduced PGE2 production.
COX Negative_regulation (reduced) of Gene_expression (production) of PGE2 in PGE2 associated with cox-2 inhibitor
2) Confidence 0.01 Published 2010 Journal Pigment Cell & Melanoma Research Section Abstract Doc Link PMC2881306 Disease Relevance 0.15 Pain Relevance 0.09
For example, in donor 37 EM, indomethacin but not the COX-2 specific inhibitor NS-398, reduced PGE2 production.
COX Negative_regulation (reduced) of Gene_expression (production) of PGE2
3) Confidence 0.01 Published 2010 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2881306 Disease Relevance 0 Pain Relevance 0.03

General Comments

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