INT314273

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.45
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGER2) signal transducer activity (PTGER2)
Uvbi1 (Mus musculus)
PTGER2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 30 98.24 Very High Very High Very High
COX-2 inhibitor 9 65.12 Quite High
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
melanocortin 1 receptor 3 5.00 Very Low Very Low Very Low
Immobilon 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 33 98.24 Very High Very High Very High
Burns 15 86.80 High High
Stress 15 48.64 Quite Low
Erythema 27 5.00 Very Low Very Low Very Low
Skin Cancer 12 5.00 Very Low Very Low Very Low
Blister 6 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 6 5.00 Very Low Very Low Very Low
Dermatitis 3 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PGE2 production in EM is increased by UVB
UVB Positive_regulation (increased) of Gene_expression (production) of PGE2
1) Confidence 0.00 Published 2010 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2881306 Disease Relevance 0.19 Pain Relevance 0.08
UVB-induced PGE2 production does not correlate with melanin content, tyrosinase expression/activity or TRP-1 or DCT expression in EM
UVB Positive_regulation (induced) of Gene_expression (production) of PGE2
2) Confidence 0.00 Published 2010 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2881306 Disease Relevance 0.08 Pain Relevance 0.04
Only EM from SPT-1 donors responded to UVB with a statistically significant increase in PGE2 production [i.e. from an average of 81 (±18) pg/million cells under basal conditions to an average of 191 (±51) pg/million cells post-UVB].


UVB Positive_regulation (increase) of Gene_expression (production) of PGE2
3) Confidence 0.00 Published 2010 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2881306 Disease Relevance 0.18 Pain Relevance 0.06

General Comments

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