INT314357

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.89
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PCK2) small molecule metabolic process (PCK2) lyase activity (PCK2)
carbohydrate metabolic process (PCK2)
Anatomy Link Frequency
liver 1
muscle 1
PCK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 1 89.44 High High
tolerance 1 62.96 Quite High
agonist 33 55.44 Quite High
Inflammation 27 30.24 Quite Low
Inflammatory response 2 22.96 Low Low
cytokine 5 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Nicotine 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 35 99.00 Very High Very High Very High
Obesity 43 95.08 Very High Very High Very High
Hyperglycemia 2 91.48 High High
Body Weight 2 79.52 Quite High
Disorder Of Lipid Metabolism 2 76.76 Quite High
Stress 6 59.68 Quite High
Diabetes Complications 1 32.12 Quite Low
INFLAMMATION 31 30.24 Quite Low
Cancer 36 28.72 Quite Low
Atherosclerosis 9 26.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, after mouse treatment with PIO, gene expression of Pepck was found to be increased in the liver by Hofmann et al. [50] but only in muscle by Suzuki et al. [49].
Gene_expression (expression) of Pepck in muscle
1) Confidence 0.16 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 1.04 Pain Relevance 0.05
Andrographolide not only reduced expression of phosphoenolpyruvate carboxykinase (PEPCK) in liver of STZ-diabetic rats, activated ?
Gene_expression (expression) of carboxykinase in liver associated with diabetes mellitus
2) Confidence 0.01 Published 2010 Journal Chin Med Section Body Doc Link PMC2881933 Disease Relevance 0.85 Pain Relevance 0.12

General Comments

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