INT31439

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Context Info
Confidence 0.55
First Reported 1985
Last Reported 1988
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 0.23
Pain Relevance 6.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk, Prl)
Anatomy Link Frequency
pituitary 2
Penk (Rattus norvegicus)
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 27 100.00 Very High Very High Very High
Enkephalin 9 100.00 Very High Very High Very High
Dynorphin 24 99.94 Very High Very High Very High
Dopamine 12 99.60 Very High Very High Very High
MU agonist 1 97.44 Very High Very High Very High
narcan 4 97.20 Very High Very High Very High
agonist 16 94.36 High High
opiate 12 94.00 High High
Substantia nigra 1 89.68 High High
antagonist 1 89.16 High High
Disease Link Frequency Relevance Heat
Schizophrenia 4 75.64 Quite High
Psychosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Diurnal variations of the effectivity of beta-endorphin (beta-End), dynorphin (DYN), Met-enkephalin (Met-Enk), D-Met2-Pro5-enkephalinamide (D-Met-Pro-Enk) and morphine to induce prolactin (PRL) and adrenocorticotropin (ACTH)/corticosterone (CS) release in intact and adrenalectomized rats have been examined.
Enk Positive_regulation (induce) of Localization (release) of prolactin associated with dynorphin, enkephalin and morphine
1) Confidence 0.55 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 2892145 Disease Relevance 0 Pain Relevance 0.63
Diurnal variations of the effectivity of beta-endorphin (beta-End), dynorphin (DYN), Met-enkephalin (Met-Enk), D-Met2-Pro5-enkephalinamide (D-Met-Pro-Enk) and morphine to induce prolactin (PRL) and adrenocorticotropin (ACTH)/corticosterone (CS) release in intact and adrenalectomized rats have been examined.
Enk Positive_regulation (induce) of Localization (release) of PRL associated with dynorphin, enkephalin and morphine
2) Confidence 0.55 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 2892145 Disease Relevance 0 Pain Relevance 0.63
Diurnal variations of the effectivity of beta-endorphin (beta-End), dynorphin (DYN), Met-enkephalin (Met-Enk), D-Met2-Pro5-enkephalinamide (D-Met-Pro-Enk) and morphine to induce prolactin (PRL) and adrenocorticotropin (ACTH)/corticosterone (CS) release in intact and adrenalectomized rats have been examined.
Enk Positive_regulation (induce) of Localization (release) of prolactin associated with dynorphin, enkephalin and morphine
3) Confidence 0.55 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 2892145 Disease Relevance 0 Pain Relevance 0.63
Diurnal variations of the effectivity of beta-endorphin (beta-End), dynorphin (DYN), Met-enkephalin (Met-Enk), D-Met2-Pro5-enkephalinamide (D-Met-Pro-Enk) and morphine to induce prolactin (PRL) and adrenocorticotropin (ACTH)/corticosterone (CS) release in intact and adrenalectomized rats have been examined.
Enk Positive_regulation (induce) of Localization (release) of PRL associated with dynorphin, enkephalin and morphine
4) Confidence 0.55 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 2892145 Disease Relevance 0 Pain Relevance 0.63
Both morphine and Met-enkephalin stimulated prolactin secretion by 1.84 fold and 1.50 fold respectively, and this was antagonised by naloxone.
Met-enkephalin Positive_regulation (stimulated) of Localization (secretion) of prolactin associated with narcan, enkephalin and morphine
5) Confidence 0.25 Published 1988 Journal Regul. Pept. Section Abstract Doc Link 3368581 Disease Relevance 0 Pain Relevance 0.86
Diurnal variations of the effectivity of beta-endorphin (beta-End), dynorphin (DYN), Met-enkephalin (Met-Enk), D-Met2-Pro5-enkephalinamide (D-Met-Pro-Enk) and morphine to induce prolactin (PRL) and adrenocorticotropin (ACTH)/corticosterone (CS) release in intact and adrenalectomized rats have been examined.
Met-enkephalin Positive_regulation (induce) of Localization (release) of prolactin associated with dynorphin, enkephalin and morphine
6) Confidence 0.16 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 2892145 Disease Relevance 0 Pain Relevance 0.63
Diurnal variations of the effectivity of beta-endorphin (beta-End), dynorphin (DYN), Met-enkephalin (Met-Enk), D-Met2-Pro5-enkephalinamide (D-Met-Pro-Enk) and morphine to induce prolactin (PRL) and adrenocorticotropin (ACTH)/corticosterone (CS) release in intact and adrenalectomized rats have been examined.
Met-enkephalin Positive_regulation (induce) of Localization (release) of PRL associated with dynorphin, enkephalin and morphine
7) Confidence 0.16 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 2892145 Disease Relevance 0 Pain Relevance 0.63
Morphine and enkephalin effectively enhance pituitary prolactin release, whereas dopamine inhibits it.
enkephalin Positive_regulation (enhance) of Localization (release) of prolactin in pituitary associated with dopamine, enkephalin and morphine
8) Confidence 0.05 Published 1985 Journal Biol. Psychiatry Section Abstract Doc Link 2996642 Disease Relevance 0.23 Pain Relevance 1.59

General Comments

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