INT31440

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Context Info
Confidence 0.76
First Reported 1987
Last Reported 1988
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0
Pain Relevance 4.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk, Prl)
Penk (Rattus norvegicus)
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 24 100.00 Very High Very High Very High
Enkephalin 13 100.00 Very High Very High Very High
Dynorphin 24 99.94 Very High Very High Very High
agonist 12 75.00 Quite High
opiate 7 75.00 Quite High
antagonist 1 69.92 Quite High
narcan 1 69.04 Quite High
Analgesic 6 25.00 Low Low
Opioid 6 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Diurnal variations of the effectivity of beta-endorphin (beta-End), dynorphin (DYN), Met-enkephalin (Met-Enk), D-Met2-Pro5-enkephalinamide (D-Met-Pro-Enk) and morphine to induce prolactin (PRL) and adrenocorticotropin (ACTH)/corticosterone (CS) release in intact and adrenalectomized rats have been examined.
Enk Positive_regulation (induce) of prolactin associated with dynorphin, enkephalin and morphine
1) Confidence 0.76 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 2892145 Disease Relevance 0 Pain Relevance 0.57
Diurnal variations of the effectivity of beta-endorphin (beta-End), dynorphin (DYN), Met-enkephalin (Met-Enk), D-Met2-Pro5-enkephalinamide (D-Met-Pro-Enk) and morphine to induce prolactin (PRL) and adrenocorticotropin (ACTH)/corticosterone (CS) release in intact and adrenalectomized rats have been examined.
Enk Positive_regulation (induce) of prolactin associated with dynorphin, enkephalin and morphine
2) Confidence 0.76 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 2892145 Disease Relevance 0 Pain Relevance 0.57
Diurnal variations of the effectivity of beta-endorphin (beta-End), dynorphin (DYN), Met-enkephalin (Met-Enk), D-Met2-Pro5-enkephalinamide (D-Met-Pro-Enk) and morphine to induce prolactin (PRL) and adrenocorticotropin (ACTH)/corticosterone (CS) release in intact and adrenalectomized rats have been examined.
Enk Positive_regulation (induce) of PRL associated with dynorphin, enkephalin and morphine
3) Confidence 0.55 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 2892145 Disease Relevance 0 Pain Relevance 0.57
Diurnal variations of the effectivity of beta-endorphin (beta-End), dynorphin (DYN), Met-enkephalin (Met-Enk), D-Met2-Pro5-enkephalinamide (D-Met-Pro-Enk) and morphine to induce prolactin (PRL) and adrenocorticotropin (ACTH)/corticosterone (CS) release in intact and adrenalectomized rats have been examined.
Enk Positive_regulation (induce) of PRL associated with dynorphin, enkephalin and morphine
4) Confidence 0.55 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 2892145 Disease Relevance 0 Pain Relevance 0.57
Met-enkephalin and both analogues increased serum growth hormone and prolactin concentration, analogue I being the most potent.
Met-enkephalin Positive_regulation (increased) of prolactin associated with enkephalin
5) Confidence 0.31 Published 1988 Journal Endocrinol. Exp. Section Abstract Doc Link 3243206 Disease Relevance 0 Pain Relevance 0.68
Diurnal variations of the effectivity of beta-endorphin (beta-End), dynorphin (DYN), Met-enkephalin (Met-Enk), D-Met2-Pro5-enkephalinamide (D-Met-Pro-Enk) and morphine to induce prolactin (PRL) and adrenocorticotropin (ACTH)/corticosterone (CS) release in intact and adrenalectomized rats have been examined.
Met-enkephalin Positive_regulation (induce) of prolactin associated with dynorphin, enkephalin and morphine
6) Confidence 0.22 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 2892145 Disease Relevance 0 Pain Relevance 0.57
Diurnal variations of the effectivity of beta-endorphin (beta-End), dynorphin (DYN), Met-enkephalin (Met-Enk), D-Met2-Pro5-enkephalinamide (D-Met-Pro-Enk) and morphine to induce prolactin (PRL) and adrenocorticotropin (ACTH)/corticosterone (CS) release in intact and adrenalectomized rats have been examined.
Met-enkephalin Positive_regulation (induce) of PRL associated with dynorphin, enkephalin and morphine
7) Confidence 0.16 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 2892145 Disease Relevance 0 Pain Relevance 0.57

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