INT31445

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Context Info
Confidence 0.01
First Reported 1985
Last Reported 1987
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ENG) extracellular region (Prl) cell motility (ENG)
cell adhesion (ENG) nucleolus (ENG) nucleus (ENG)
ENG (Homo sapiens)
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 8 100.00 Very High Very High Very High
Dynorphin 8 100.00 Very High Very High Very High
Enkephalin 2 100.00 Very High Very High Very High
antagonist 5 99.46 Very High Very High Very High
narcan 4 89.40 High High
Opioid 3 87.04 High High
opiate 3 79.60 Quite High
opioid receptor 2 76.52 Quite High
agonist 4 75.00 Quite High
Analgesic 2 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Diurnal variations of the effectivity of beta-endorphin (beta-End), dynorphin (DYN), Met-enkephalin (Met-Enk), D-Met2-Pro5-enkephalinamide (D-Met-Pro-Enk) and morphine to induce prolactin (PRL) and adrenocorticotropin (ACTH)/corticosterone (CS) release in intact and adrenalectomized rats have been examined.
beta-End Positive_regulation (induce) of Localization (release) of prolactin associated with dynorphin, enkephalin and morphine
1) Confidence 0.01 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 2892145 Disease Relevance 0 Pain Relevance 0.63
Diurnal variations of the effectivity of beta-endorphin (beta-End), dynorphin (DYN), Met-enkephalin (Met-Enk), D-Met2-Pro5-enkephalinamide (D-Met-Pro-Enk) and morphine to induce prolactin (PRL) and adrenocorticotropin (ACTH)/corticosterone (CS) release in intact and adrenalectomized rats have been examined.
beta-End Positive_regulation (induce) of Localization (release) of PRL associated with dynorphin, enkephalin and morphine
2) Confidence 0.01 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 2892145 Disease Relevance 0 Pain Relevance 0.63
TRH stimulatory activity of TSH and PRL secretion was blunted by the presence of beta h-End (10(-7) M) and was not reversed by NAL (10(-5) and 10(-3) M).
h-End Positive_regulation (blunted) of Localization (secretion) of PRL
3) Confidence 0.01 Published 1986 Journal Horm. Res. Section Abstract Doc Link 2944810 Disease Relevance 0 Pain Relevance 0.12
None of the antagonists significantly reduced the beta-END-induced release of PRL.
beta-END Positive_regulation (induced) of Localization (release) of PRL associated with antagonist
4) Confidence 0.00 Published 1985 Journal Endocrinology Section Abstract Doc Link 2981076 Disease Relevance 0 Pain Relevance 0.38

General Comments

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