INT31450

Context Info Confidence 0.37 First Reported 1981 Last Reported 2010 Negated 1 Speculated 2 Reported most in Body Documents 20 Total Number 22 Disease Relevance 10.21 Pain Relevance 2.84

chromosome (HIST1H1B) nucleus (HIST1H1B) DNA binding (HIST1H1B)

Anatomy Link Frequency respiratory tract epithelium 1 HIST1H1B (Homo sapiens)

Pain Link Frequency Relevance Heat Antihistamine 21 99.84 Potency 9 99.72 antagonist 36 99.68 noradrenaline 27 99.26 Serotonin 40 98.60 Dopamine 19 96.56 antidepressant 44 92.40 corticosteroid 14 92.32 gABA 4 91.60 cytokine 20 89.12

Disease Link Frequency Relevance Heat Stroke 287 99.76 Anaphylaxis 110 99.48 Influenza In Birds 8 99.40 Immunization 19 97.68 Sprains And Strains 31 97.64 Influenza Virus Infection 209 97.60 Sneezing 8 95.56 Sleep Disorders 24 95.00 Toxicity 21 93.68 Disease 115 92.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Antihistamines act by competing with histamine for H1 or H2 histamine receptors on cell membranes.

H1 Binding (competing) of associated with antihistamine

1) Confidence 0.37 Published 1987 Journal Ann Allergy Section Abstract Doc Link 2892449 Disease Relevance 0.08 Pain Relevance 0.20

The relative noradrenaline/serotonin reuptake inhibition, lipid solubility and their potency at histamine H1, muscarinic and alpha 1-adrenergic receptors had no substantial association with the FTI.

H1 Neg (no) Binding (association) of associated with noradrenaline, serotonin and potency

2) Confidence 0.37 Published 1998 Journal Drug Saf Section Abstract Doc Link 9589848 Disease Relevance 0.40 Pain Relevance 0.69

In vitro antagonism of benzodiazepine binding to cerebral receptors by H1 and H2 antihistamines.

H1 Binding (binding) of associated with antihistamine

3) Confidence 0.28 Published 1981 Journal J. Lab. Clin. Med. Section Title Doc Link 6108979 Disease Relevance 0.10 Pain Relevance 0.38

It also has additional antagonistic affinity for the histaminic H1 and adrenergic ?

H1 Binding (affinity) of

4) Confidence 0.18 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770423 Disease Relevance 0.14 Pain Relevance 0.05

In fact, for some agents (eg, quetiapine, clozapine) the affinity for the H1 and ?

H1 Binding (affinity) of

5) Confidence 0.14 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770423 Disease Relevance 0.43 Pain Relevance 0

Even though we only had 50% power, we detected an association of H1 at a significance level of 0.001, and this association would survive a Bonferroni correction for the seventeen crude or adjusted association tests performed for haplogroups, suggesting that it is an important association.

H1 Binding (association) of

6) Confidence 0.13 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2492853 Disease Relevance 0.24 Pain Relevance 0.03

Stratification by sex was performed as there are clear differences between male and female ischemic patients [33], and some of the associations (e.g. adjusted association of H1 in females) most likely did not reach statistical significance due to the relatively small sample sizes.

H1 Spec (clear) Binding (association) of

7) Confidence 0.13 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2492853 Disease Relevance 0.60 Pain Relevance 0.08

Reboxetine is a potent, selective, and specific noradrenaline reuptake inhibitor, with negligible affinity for muscarinic, H1, ?

H1 Binding (affinity) of associated with noradrenaline

8) Confidence 0.11 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938284 Disease Relevance 0 Pain Relevance 0.41

SNPs m.3010G>A, m.7028C>T and m.11719G>A, which together define H1, were found to consistently influence the risk for ischemic stroke in both the uncorrected ?

H1 Binding (define) of associated with stroke

9) Confidence 0.09 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2492853 Disease Relevance 0.54 Pain Relevance 0

We found suggestive evidence for association of the mitochondrial haplogroup H1 with ischemic stroke.

H1 Binding (association) of associated with stroke

10) Confidence 0.08 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2492853 Disease Relevance 0.62 Pain Relevance 0

Stratification by sex revealed that the crude association of haplogroup H1 is quite consistent among males (OR = 0.65, 95%CI = 0.43–0.98, p = 0.038) and females (OR = 0.58, 95%CI = 0.37–0.93, p = 0.021), even though it did not reach significance in females when adjusted for co-variates (Figure 2), most likely due to the small sample size.

H1 Spec (likely) Binding (association) of

11) Confidence 0.08 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2492853 Disease Relevance 0.54 Pain Relevance 0

Several reports on the treatment of anaphylaxis have demonstrated that a combination of H1 and H2 antagonists is more effective than treatment with an H1 antagonist alone [24].

H1 Binding (combination) of associated with anaphylaxis and antagonist

12) Confidence 0.08 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2873621 Disease Relevance 0.92 Pain Relevance 0.56

0.02, H1 p?

H1 Binding (0.02) of

13) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877091 Disease Relevance 0.78 Pain Relevance 0.08

Predominantly human subtypes (H1, H2, and H3) bind to alpha-2,6-galactose sialic acid found in ciliated human respiratory tract epithelium [18].

H1 Binding (bind) of in respiratory tract epithelium

14) Confidence 0.06 Published 2008 Journal Crit Care Section Body Doc Link PMC2575602 Disease Relevance 0.87 Pain Relevance 0

The tagging SNPs for H1 were individually associated with higher CRP levels.

H1 Binding (associated) of

15) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148071 Disease Relevance 0.24 Pain Relevance 0

For comparison, H1 and H5, which included the triallelic proxy, were both associated with higher CRP levels.

H1 Binding (associated) of

16) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148071 Disease Relevance 0.33 Pain Relevance 0

Ki (affinity) values of the olopatadine hydrochloride binding to H1, H2, and H3 receptors were 4.11 × 10?

H1 Binding (binding) of

17) Confidence 0.04 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2694001 Disease Relevance 0.43 Pain Relevance 0

CR6261 has been shown to recognize H1 viruses that have emerged over a time span of 90 years from the H1N1 virus which caused the 1918 ‘Spanish flu’ pandemic to the latest Brisbane viruses.

H1 Binding (recognize) of

18) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817000 Disease Relevance 0.89 Pain Relevance 0

Affinity for H1, H2, and H3 receptors was examined using pyrilamine, tiotidine, and methylhistamine as the ligand, respectively.

H1 Binding (Affinity) of

19) Confidence 0.04 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2694001 Disease Relevance 0.48 Pain Relevance 0

It also binds with high affinity to H1 and M1 receptors.

H1 Binding (binds) of

20) Confidence 0.03 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2987508 Disease Relevance 0.43 Pain Relevance 0.37

General Comments

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