INT31451

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Context Info
Confidence 0.43
First Reported 1987
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.03
Pain Relevance 2.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra2a) plasma membrane (Adra2a) cytoplasm (Adra2a)
signal transducer activity (Adra2a)
Anatomy Link Frequency
brainstem 1
hippocampus 1
Adra2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 12 100.00 Very High Very High Very High
Morphine 8 100.00 Very High Very High Very High
medulla 2 100.00 Very High Very High Very High
intrathecal 1 100.00 Very High Very High Very High
antagonist 4 99.96 Very High Very High Very High
Hippocampus 3 99.84 Very High Very High Very High
Serotonin 2 98.28 Very High Very High Very High
Inflammation 3 97.44 Very High Very High Very High
Hyperalgesia 1 96.64 Very High Very High Very High
Opioid 3 95.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1 97.44 Very High Very High Very High
Hypertension 4 96.96 Very High Very High Very High
Hyperalgesia 1 96.64 Very High Very High Very High
Inflammatory Pain 1 91.56 High High
Pain 5 86.56 High High
Opiate Addiction 2 81.44 Quite High
Drug Dependence 1 79.00 Quite High
Heart Rate Under Development 1 46.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intrathecal pretreatment with antisense ODN to alpha2A-adrenergic receptors reduced alpha2A-adrenergic receptor protein expression compared with sense ODN control and also reduced clonidine-induced inhibition of [3H]NE release.
Negative_regulation (reduced) of Gene_expression (expression) of alpha2A-adrenergic
1) Confidence 0.43 Published 2000 Journal Anesthesiology Section Body Doc Link 10861160 Disease Relevance 0 Pain Relevance 0
In pentobarbital-anesthetized rats, pressor responses to i.c.v. injection of alpha 1- and alpha 2-adrenoceptor agonists were significantly inhibited and a long-lasting depressor response was induced by alpha 2-adrenoceptor agonists, whereas depressor responses to alpha 1-adrenoceptor agonists were not affected.
Negative_regulation (injection) of Gene_expression (agonists) of 2-adrenoceptor associated with agonist
2) Confidence 0.20 Published 1987 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 2892472 Disease Relevance 0.26 Pain Relevance 0.44
Yohimbine prevents morphine-induced changes of glial fibrillary acidic protein in brainstem and alpha2-adrenoceptor gene expression in hippocampus.
Negative_regulation (prevents) of in brainstem Gene_expression (expression) of alpha2-adrenoceptor in hippocampus associated with medulla, hippocampus and morphine
3) Confidence 0.09 Published 2007 Journal Neurosci. Lett. Section Title Doc Link 17123717 Disease Relevance 0.16 Pain Relevance 0.94
This effect was attenuated after intrathecal administration of the alpha2-adrenoceptor antagonist yohimbine, the selective 5-HT3 serotonin receptor antagonist MDL72222, and the non-selective serotonin receptor antagonist methysergide.
Negative_regulation (attenuated) of Gene_expression (administration) of alpha2-adrenoceptor associated with antagonist, serotonin and intrathecal
4) Confidence 0.07 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18539061 Disease Relevance 0.61 Pain Relevance 1.34

General Comments

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