INT314511

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.68
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (TH) cytosol (TH) mitochondrion (TH)
small molecule metabolic process (TH) nucleus (TH) cellular nitrogen compound metabolic process (TH)
TH (Homo sapiens)
Pain Link Frequency Relevance Heat
carbamazepine 3 98.90 Very High Very High Very High
tolerance 3 97.32 Very High Very High Very High
Biofeedback 1 79.04 Quite High
agonist 15 76.80 Quite High
Dopamine 44 76.44 Quite High
Pain 2 35.28 Quite Low
midbrain 1 18.88 Low Low
Spinal cord 1 17.44 Low Low
antagonist 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Restless Legs Syndrome 84 91.32 High High
Hypothyroidism 4 70.40 Quite High
Syndrome 4 66.20 Quite High
Sleep Disorders 22 50.00 Quite Low
Thyroid Disease 7 47.44 Quite Low
Pain 2 35.28 Quite Low
Disease 6 27.04 Quite Low
Graves' Ophthalmopathy 1 16.40 Low Low
Nociception 2 13.04 Low Low
Anaemia 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This drug, an inducer and substrate of CYP450, slowly causes tolerance because the induction of CYP also increases the speed with which carbamazepine itself is metabolized, rendering it less effective at inducing metabolism of TH.
Positive_regulation (inducing) of TH Binding (metabolism) of associated with tolerance and carbamazepine
1) Confidence 0.04 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2882550 Disease Relevance 0.68 Pain Relevance 0.38

General Comments

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