INT314554

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Context Info
Confidence 0.74
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 25
Disease Relevance 7.97
Pain Relevance 2.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Fgf21)
Anatomy Link Frequency
liver 2
muscle 1
acinar cells 1
adipose tissue 1
fibroblast 1
Fgf21 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 35 99.28 Very High Very High Very High
Bile 368 98.84 Very High Very High Very High
cytokine 23 73.92 Quite High
Pain 23 34.52 Quite Low
Eae 24 5.00 Very Low Very Low Very Low
Spinal cord 23 5.00 Very Low Very Low Very Low
sodium channel 23 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 394 99.60 Very High Very High Very High
Targeted Disruption 865 99.58 Very High Very High Very High
Eating Disorder 23 98.72 Very High Very High Very High
Syndrome 23 97.80 Very High Very High Very High
Pancreatitis 23 96.76 Very High Very High Very High
Injury 23 95.68 Very High Very High Very High
Diabetes Mellitus 48 92.36 High High
Metabolic Disorder 184 88.96 High High
Starvation 46 88.80 High High
Fatty Liver 115 88.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the regulatory mechanism of Fgf21 expression remains unclear.
Gene_expression (expression) of Fgf21
1) Confidence 0.74 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.17 Pain Relevance 0.17
Fgf21 is also expressed in the pancreas, white adipose tissue, and muscle (Nishimura et al 2000; Kharitonenkov and Shanafelt 2009).
Gene_expression (expressed) of Fgf21 in muscle associated with obesity
2) Confidence 0.74 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.25 Pain Relevance 0.06
Later, Fgf15/19, Fgf21, and Fgf23 were generated by two large-scale genome duplication events during the evolution of early vertebrates
Gene_expression (generated) of Fgf21
3) Confidence 0.74 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0 Pain Relevance 0
(Fgf21) Hepatic Fgf21 expression is induced by the activation of PPAR?.
Gene_expression (expression) of Fgf21
4) Confidence 0.74 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.13 Pain Relevance 0.22
forms a heterodimer with RXRs and induces the expression of Fgf21.
Gene_expression (expression) of Fgf21
5) Confidence 0.74 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.17 Pain Relevance 0.20
The expression of Fgf21 was also induced in the liver by a high-fat, low-carbohydrate ketogenic diet.
Gene_expression (expression) of Fgf21 in liver
6) Confidence 0.74 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.74 Pain Relevance 0
Fgf21 expression was markedly increased in mouse pancreatic acinar cells during cerulein-induced pancreatitis and following injury in vitro.
Gene_expression (expression) of Fgf21 in acinar cells associated with injury and pancreatitis
7) Confidence 0.74 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.68 Pain Relevance 0
In mice, Fgf21 is most abundantly expressed in the liver.
Gene_expression (expressed) of Fgf21 in liver
8) Confidence 0.64 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.24 Pain Relevance 0.07
(Fgf21) Hepatic Fgf21 expression is induced by the activation of PPAR?.
Gene_expression (expression) of Fgf21
9) Confidence 0.64 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.13 Pain Relevance 0.22
Klotho knockout mice indicates that Fgf21 signals are transduced in the absence of ?
Gene_expression (signals) of Fgf21 associated with targeted disruption
10) Confidence 0.64 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.62 Pain Relevance 0.07
Hepatic Fgf21 expression is induced directly by PPAR?
Gene_expression (expression) of Fgf21
11) Confidence 0.64 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.67 Pain Relevance 0
forms a heterodimer with RXRs and induces the expression of Fgf21.
Gene_expression (expression) of Fgf21
12) Confidence 0.57 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.23 Pain Relevance 0.18
The regulatory mechanism of Fgf21 expression remains unclear (Fig. 2).


Gene_expression (expression) of Fgf21
13) Confidence 0.57 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.15 Pain Relevance 0.09
Later, Fgf15/19, Fgf21, and Fgf23 were generated from the ancestral gene by genome duplication events.
Gene_expression (generated) of Fgf21
14) Confidence 0.57 Published 2010 Journal Cell Tissue Res Section Abstract Doc Link PMC2948652 Disease Relevance 0.08 Pain Relevance 0
Hepatic Fgf21 expression is greatly induced in wild-type mice but not PPAR?
Gene_expression (expression) of Fgf21
15) Confidence 0.57 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.28 Pain Relevance 0.21
In contrast, serum Fgf21 levels are decreased in patients with anorexia nervosa (Table 2) (Dostálová et al. 2008).


Gene_expression (levels) of Fgf21 associated with eating disorder
16) Confidence 0.57 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 1.33 Pain Relevance 0.03
These results indicate that hepatic Fgf21 expression is induced by the activation of PPAR?.
Gene_expression (expression) of Fgf21
17) Confidence 0.57 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.23 Pain Relevance 0.20
Later, Fgf19, Fgf21, and Fgf23 were generated from Fgf19-like by two large-scale genome duplication events (Itoh and Ornitz 2004; Itoh and Ornitz 2008).
Gene_expression (generated) of Fgf21
18) Confidence 0.57 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0 Pain Relevance 0
Hepatic Fgf21 expression during fasting might be induced through the activation of PPAR?
Gene_expression (expression) of Fgf21
19) Confidence 0.57 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.18 Pain Relevance 0.17
However, although hepatic Fgf21 expression is greatly induced in wild-type mice by fasting for 24 h, serum NEFA levels are essentially unchanged (Badman et al. 2007; Hotta et al. 2009).
Gene_expression (expression) of Fgf21
20) Confidence 0.57 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.17 Pain Relevance 0.13

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