INT314571

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.88
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Tbk1) cytoplasm (Tbk1)
Tbk1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 22 97.60 Very High Very High Very High
Inflammation 48 94.48 High High
alcohol 2 79.68 Quite High
depression 8 71.60 Quite High
Paracetamol 248 54.88 Quite High
fibrosis 8 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Multiple sclerosis 6 5.00 Very Low Very Low Very Low
Analgesic 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 16 94.84 High High
INFLAMMATION 48 94.48 High High
Hepatitis B Virus Infection 16 90.48 High High
Targeted Disruption 26 82.28 Quite High
Hepatocellular Cancer 94 79.36 Quite High
Nash(non-alcoholic Steatohepatitis) 18 78.04 Quite High
Alcoholic Liver Diseases 4 77.64 Quite High
Liver Disease 8 73.24 Quite High
Depression 8 71.60 Quite High
Obesity 6 51.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The NS3 protein interacts directly with TBK1, resulting in decreased TBK1-IRF3 interaction and inhibition of IRF3 and IFN transcription.
TBK1 Binding (interacts) of
1) Confidence 0.24 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.33 Pain Relevance 0.20
The NS3 protein interacts directly with TBK1, resulting in decreased TBK1-IRF3 interaction and inhibition of IRF3 and IFN transcription.
TBK1 Neg (inhibition) Binding (interaction) of
2) Confidence 0.23 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.41 Pain Relevance 0.20
Zbp1 activation of IRF3 is dependent on the recruitment of TBK-1 (TANK-binding kinase-1) and an I?
TANK-binding kinase-1 Binding (recruitment) of
3) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882945 Disease Relevance 0.07 Pain Relevance 0.14
Zbp1 activation of IRF3 is dependent on the recruitment of TBK-1 (TANK-binding kinase-1) and an I?
TBK-1 Binding (recruitment) of
4) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882945 Disease Relevance 0.07 Pain Relevance 0.14

General Comments

This test has worked.

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