INT314679
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
It was reported that HER2 overexpression in p53 wild-type human ovarian carcinoma cell line induced apoptosis shortly after transfection, while HER2 expression was associated with proliferation in cells with mutated p53.109 It was also reported that HER2/neu induces p53 ubiquitination via Akt-mediated Mdm2 phosphorylation and inactivates p53 in Arf-deficient cells.110 Thus, both ARF and p53 are important genetic determinants in susceptibility to HER2 overexpression in breast cancer. | |||||||||||||||
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