INT314679

Context Info Confidence 0.12 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.23 Pain Relevance 0

cell differentiation (TP53) nucleoplasm (TP53) mitochondrion (TP53) DNA binding (TP53) plasma membrane (NEU1) nucleus (TP53)

NEU1 (Homo sapiens) TP53 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 5 5.00 palliative 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 5 97.08 Ovarian Cancer 3 96.52 Breast Cancer 123 94.80 Cancer 91 76.32 Recurrence 9 68.96 Disease 16 64.48 Death 4 7.16 Metastasis 10 5.00 Carcinoma 7 5.00 Malignant Neoplastic Disease 6 5.00

Sentences Mentioned In

Key:

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Mutation

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Anatomy

Negation

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It was reported that HER2 overexpression in p53 wild-type human ovarian carcinoma cell line induced apoptosis shortly after transfection, while HER2 expression was associated with proliferation in cells with mutated p53.109 It was also reported that HER2/neu induces p53 ubiquitination via Akt-mediated Mdm2 phosphorylation and inactivates p53 in Arf-deficient cells.110 Thus, both ARF and p53 are important genetic determinants in susceptibility to HER2 overexpression in breast cancer.

neu Negative_regulation (inactivates) of p53 associated with breast cancer, ovarian cancer and apoptosis

1) Confidence 0.12 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.23 Pain Relevance 0

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