INT314680

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Context Info
Confidence 0.34
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.16
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (TBX2, CDKN2A) nucleus (TBX2, CDKN2A) nucleoplasm (CDKN2A)
protein complex (CDKN2A) cytoplasm (CDKN2A) cytosol (CDKN2A)
TBX2 (Homo sapiens)
CDKN2A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 5 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 1 100.00 Very High Very High Very High
Aging 5 99.36 Very High Very High Very High
Cancer 91 99.34 Very High Very High Very High
Breast Cancer 123 90.72 High High
Polyploidy 1 75.20 Quite High
Syndrome 2 71.44 Quite High
Bladder Cancer 2 22.76 Low Low
Disease 16 5.00 Very Low Very Low Very Low
Metastasis 10 5.00 Very Low Very Low Very Low
Recurrence 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is a particularly important question because the loss of CDKN2 A in many human cancers would, in principle, bypass the requirement for Tbx2/3-mediated repression of ARF in suppressing senescence (Fig. 1).
Positive_regulation (requirement) of Tbx2 Negative_regulation (repression) of ARF associated with aging, cancer and repression
1) Confidence 0.34 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.16 Pain Relevance 0

General Comments

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