INT314687

Context Info Confidence 0.27 First Reported 2010 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.88 Pain Relevance 0

nucleoplasm (ESR1, PGR) enzyme binding (ESR1, PGR) DNA binding (ESR1, PGR) cytoplasm (ESR1, PGR) signal transduction (ESR1, PGR) nucleus (ESR1, PGR)

Anatomy Link Frequency epithelium 1 ESR1 (Homo sapiens) PGR (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 5 5.00 palliative 1 5.00

Disease Link Frequency Relevance Heat Breast Cancer 123 96.88 Cancer 91 89.08 Noninfiltrating Intraductal Carcinoma 2 81.04 Recurrence 9 24.56 Disease 16 5.00 Metastasis 10 5.00 Carcinoma 7 5.00 Malignant Neoplastic Disease 6 5.00 Targeted Disruption 6 5.00 Aging 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

In many breast tumor cell lines—and in normal tissues containing ER, such as the endometrium and brain—PR expression is induced by estrogen.51,52 It is still not known whether ER regulates PR in normal human mammary epithelium in precisely the same subpopulation of ductal and lobular luminal cells, although this assumption is considered to be likely.

ER Spec (whether) Regulation (regulates) of PR in epithelium associated with breast cancer

1) Confidence 0.27 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.88 Pain Relevance 0

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