INT314688

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.41
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CCNE1, CDK2) cytoplasm (CCNE1, CDK2) cytosol (CCNE1, CDK2)
nucleus (CCNE1, CDK2) kinase activity (CCNE1, CDK2) cell division (CCNE1, CDK2)
CCNE1 (Homo sapiens)
CDK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 10 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Genomic Instability 4 96.60 Very High Very High Very High
Cancer 182 94.60 High High
Breast Cancer 246 92.20 High High
Malignant Neoplastic Disease 12 70.52 Quite High
Disease 32 39.72 Quite Low
Death 8 31.76 Quite Low
Aging 10 19.40 Low Low
Metastasis 20 15.28 Low Low
Recurrence 18 5.00 Very Low Very Low Very Low
Carcinoma 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two proteins codified by two different genes but with high homology, called cyclin E1 (formerly cyclin E) and cyclin E2 have been identified.173–177 Cyclin E2, like cyclin E1, associates with Cdk2 and activates its kinase activity at the G1/S boundary.176 Cyclin E2 shares 47% overall similarity to cyclin E1; whether its structural features outside the conserved regions reveal unique functions is unknown.176
cyclin E1 Binding (associates) of Cdk2
1) Confidence 0.04 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.70 Pain Relevance 0
Two proteins codified by two different genes but with high homology, called cyclin E1 (formerly cyclin E) and cyclin E2 have been identified.173–177 Cyclin E2, like cyclin E1, associates with Cdk2 and activates its kinase activity at the G1/S boundary.176 Cyclin E2 shares 47% overall similarity to cyclin E1; whether its structural features outside the conserved regions reveal unique functions is unknown.176
cyclin E1 Binding (associates) of Cdk2
2) Confidence 0.04 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.72 Pain Relevance 0

General Comments

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