INT314712

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Context Info
Confidence 0.22
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.43
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MYC) chromosome organization (MYC) nucleolus (MYC)
nucleus (MYC) DNA binding (MYC) protein complex (MYC)
MYC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 5 94.44 High High
palliative 1 62.88 Quite High
Somatostatin 4 14.92 Low Low
imagery 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 113 99.76 Very High Very High Very High
Disease 16 99.40 Very High Very High Very High
Carcinoma 7 94.88 High High
INFLAMMATION 2 94.44 High High
Breast Cancer 123 92.44 High High
Pituitary Cancer 39 89.60 High High
Targeted Disruption 6 75.84 Quite High
Neurodegenerative Disease 1 75.56 Quite High
Colon Cancer 1 69.84 Quite High
Apoptosis 11 55.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ER/PR-negative tumors are often associated with aggressive disease, and these tumors frequently show amplification of HER2, c-Myc, and Int2 oncogenes, and mutations of the p53 tumor suppressor gene.
Negative_regulation (show) of Localization (amplification) of c-Myc associated with cancer and disease
1) Confidence 0.22 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.14 Pain Relevance 0.11
The potential target genes of miR-145 encode oncogenic proteins, such as myc, kras, fos, yes, fli, cyclin D2, and MAPK transduction proteins [31]. miR-145 targets the insulin receptor substrate-1 (IRS-1) and miR-151-3p targets the insulin receptor substrate-4 (IRS-4), which regulated cell communication, receptor and membrane activities.
Negative_regulation (yes) of Localization (kras) of myc
2) Confidence 0.15 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3017030 Disease Relevance 0.29 Pain Relevance 0

General Comments

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