INT314715

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Context Info
Confidence 0.23
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.24
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCND2) nucleolus (CCND2) nucleus (CCND2)
cell division (CCND2) cytoplasm (CCND2)
Anatomy Link Frequency
mammary glands 2
CCND2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 5 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 123 99.84 Very High Very High Very High
Aging 5 97.76 Very High Very High Very High
Disease 16 90.20 High High
Glioma 26 82.72 Quite High
Cancer 126 78.00 Quite High
Retinoblastoma 1 75.36 Quite High
Metastasis 12 69.44 Quite High
Recurrence 9 68.64 Quite High
Malignant Neoplastic Disease 6 18.96 Low Low
Apoptosis 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, MMTV-cyclin D2 mice show increased proliferation of mammary glands in pregnant females, but alveolar differentiation is partially or completely inhibited.157 In one report, cyclin D3 was overexpressed in breast cancers, but there are limited data on its relationship to the phenotype of breast cancer and prognosis of patients.158 Keyomarsi et al showed that the absence of cyclin D1 or cyclin D3 protein expression was associated with improved disease-specific and overall survival, but the correlations were less striking than those for cyclin E.159

Cyclin E

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of MMTV-cyclin D2 in mammary glands associated with breast cancer and disease
1) Confidence 0.23 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.93 Pain Relevance 0
Therefore, the G0/G1 arrest induced by the treatments could be due to the combined action of reduced cyclin D1, cyclin D2, and cyclin E-Cdk2 complex formation and increased expression of p27Kip1.
Positive_regulation (increased) of Gene_expression (expression) of cyclin D2
2) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.31 Pain Relevance 0

General Comments

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