INT314716

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.48
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCNE1) nucleoplasm (CCNE1) nucleolus (CCNE1)
nucleus (CCNE1) cell division (CCNE1) kinase activity (CCNE1)
CCNE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 10 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 246 98.28 Very High Very High Very High
Disease 32 90.88 High High
Cancer 182 90.60 High High
Genomic Instability 4 83.20 Quite High
Malignant Neoplastic Disease 12 57.12 Quite High
Death 8 51.60 Quite High
Metastasis 20 35.12 Quite Low
Aging 10 6.00 Low Low
Recurrence 18 5.00 Very Low Very Low Very Low
Carcinoma 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased expression of cyclin E1 has been reported in approximately 40% of breast cancer cases,159,178,179 and of cyclin E2 in 38% of primary ER-negative breast cancers.176 Elevated levels of both cyclins were more frequently found in ER-negative than in ER-positive tumors.176 The prognostic role of cyclin E (E1) has been retrospectively evaluated in a number of studies.180–187 Keyomarsi et al found that the overexpression of the cyclin E protein was accompanied by the appearance of low molecular weight (LMW) isoforms, and both were a reliable prognostic marker in stage I–III breast cancer patients.
Positive_regulation (Increased) of Gene_expression (expression) of cyclin E1 associated with cancer and breast cancer
1) Confidence 0.16 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.89 Pain Relevance 0
Likewise, overexpression of the low molecular weight form of cyclin E1 protein predicts poor prognosis.
Positive_regulation (overexpression) of Gene_expression (overexpression) of cyclin E1
2) Confidence 0.12 Published 2010 Journal Clinical Medicine Insights. Oncology Section Abstract Doc Link PMC2883240 Disease Relevance 0.59 Pain Relevance 0

General Comments

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