INT314731

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.42
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TBX2) DNA binding (TBX2)
TBX2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 15 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 369 99.60 Very High Very High Very High
Polyploidy 3 99.26 Very High Very High Very High
Cancer 273 98.94 Very High Very High Very High
Aging 15 97.42 Very High Very High Very High
Syndrome 6 94.20 High High
Repression 3 91.64 High High
Bladder Cancer 6 39.72 Quite Low
Disease 48 5.00 Very Low Very Low Very Low
Metastasis 30 5.00 Very Low Very Low Very Low
Recurrence 27 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TBX3 is required for normal mammary development in mouse models and in patients with ulnar-mammary syndrome (UMS).123 TBX2 and TBX3 also have been implicated in tumor development through downregulation of the ARF tumor suppressor and an associated bypass of senescence.124,125 Overexpression of Bmi1, Pokemon, and Twist also contribute to tumor formation by repressing the INK4a/ARF locus.126 The TBX2 gene encoding a key developmental transcription factor is amplified and overexpressed in BRCA1 and BRCA2-mutated breast tumors.127 However, it is not known how Tbx2 mediates its repressive effect, nor whether endogenous Tbx2 or Tbx3 have a similar anti-senescence function in transformed cells.
Spec (whether) Positive_regulation (overexpressed) of Gene_expression (overexpressed) of TBX2 associated with aging, cancer, syndrome and breast cancer
1) Confidence 0.41 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.22 Pain Relevance 0
Ectopic expression of Tbx2 results in DNA polyploidy and cisplatin resistance. 128 Thus, overexpression of Tbx2 contributes to breast carcinogenesis by accelerating cell proliferation, changing DNA ploidy, and making cells resistant to chemotherapy.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Tbx2 associated with polyploidy
2) Confidence 0.38 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.07 Pain Relevance 0
It has been reported that TBX2 is amplified in 8.6 to 21.6 % of sporadic human breast carcinomas, where the protein is overexpressed.122 A representative picture of TBX2 overexpression in human breast cancer is shown in Figure 2c.
Positive_regulation (overexpression) of Gene_expression (overexpression) of TBX2 associated with breast cancer
3) Confidence 0.38 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.13 Pain Relevance 0

General Comments

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