INT314756

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 4.58
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6, Crp) aging (IL6) extracellular region (IL6)
Anatomy Link Frequency
liver 2
IL6 (Homo sapiens)
Crp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 10 99.92 Very High Very High Very High
cytokine 10 98.08 Very High Very High Very High
diabetic neuropathy 9 95.32 Very High Very High Very High
antagonist 2 91.68 High High
peripheral neuropathy 2 72.00 Quite High
cva 2 34.32 Quite Low
abdominal pain 2 31.60 Quite Low
headache 2 30.56 Quite Low
Bioavailability 1 21.36 Low Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 8 99.92 Very High Very High Very High
Hepatocellular Cancer 2 98.88 Very High Very High Very High
Diabetic Neuropathy 9 95.32 Very High Very High Very High
Disease 41 94.64 High High
Neuropathy 68 94.56 High High
Sepsis 4 93.52 High High
Hantavirus Infection 94 93.48 High High
Necrosis 2 89.88 High High
Cancer 4 89.52 High High
Diabetes Mellitus 19 89.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-6 is the main inducer of CRP production in vitro in cultured human hepatoma cells [20], but data about the associations of IL-6 and CRP in vivo is scarce.
IL-6 Positive_regulation (inducer) of Gene_expression (production) of CRP associated with hepatocellular cancer
1) Confidence 0.13 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2885391 Disease Relevance 1.56 Pain Relevance 0.31
Finally, there was a positive correlation between maximum IL-6 and CRP levels in the present study, which can be explained by the fact that IL-6 induces the production of CRP.
IL-6 Positive_regulation (induces) of Gene_expression (production) of CRP
2) Confidence 0.13 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2885391 Disease Relevance 1.13 Pain Relevance 0
CRP is an acute phase protein that is produced in the liver and induced by IL-6 mainly [12].
IL-6 Positive_regulation (induced) of Gene_expression (produced) of CRP in liver
3) Confidence 0.00 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883349 Disease Relevance 1.82 Pain Relevance 0.18

General Comments

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