INT314837

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Context Info
Confidence 0.32
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.75
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (Chek2) nucleus (Chek2) cell cycle (Chek2)
cell division (Chek2) kinase activity (Chek2)
Anatomy Link Frequency
eye 1
Chek2 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 12 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Neuritis 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 9 99.76 Very High Very High Very High
Hypocalcemia 3 99.16 Very High Very High Very High
Cancer 15 99.08 Very High Very High Very High
Pressure And Volume Under Development 3 96.88 Very High Very High Very High
Autosomal Dominant Optic Atrophy 3 96.08 Very High Very High Very High
Digeorge Syndrome 3 95.88 Very High Very High Very High
Glaucoma 93 90.64 High High
Optic Atrophy 3 78.20 Quite High
Ganglion Cysts 9 64.00 Quite High
Syndrome 12 33.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regarding the association of CHEK2 with breast cancer, it is of interest that also one borderline significant SNP is located in a gene breast carcinoma amplified sequence 3 (BCAS3) involved in this pathway.
CHEK2 Binding (association) of associated with breast cancer
1) Confidence 0.32 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2883590 Disease Relevance 0.94 Pain Relevance 0
A literature search did not show a direct link between CHEK2 and the eye, however one study reported mapping of a locus on chromosome 22q12.1–q13.1 (OPA5) to autosomal dominant optic atrophy [40] and one case-report described an association of chromosome 22q11.2 deletion syndrome with optic disc swelling, which is probably caused by the resulting hypocalcaemia [41].
CHEK2 Neg (not) Binding (link) of in eye associated with hypocalcemia, pressure and volume under development, autosomal dominant optic atrophy and digeorge syndrome
2) Confidence 0.28 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2883590 Disease Relevance 0.92 Pain Relevance 0
Finally, the CHEK2 gene has been associated with several types of cancer, including breast cancer [39].
CHEK2 Binding (associated) of associated with cancer and breast cancer
3) Confidence 0.27 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2883590 Disease Relevance 0.90 Pain Relevance 0

General Comments

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