INT31494

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Context Info
Confidence 0.12
First Reported 1986
Last Reported 1995
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.13
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Pomc, Crh) extracellular space (Pomc, Crh) extracellular region (Pomc, Crh)
response to stress (Crh) cell-cell signaling (Pomc) generation of precursor metabolites and energy (Pomc)
Pomc (Rattus norvegicus)
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 3 100.00 Very High Very High Very High
narcan 5 98.22 Very High Very High Very High
Endogenous opioid 1 96.52 Very High Very High Very High
opiate 3 87.64 High High
antagonist 3 81.52 Quite High
dexamethasone 4 81.28 Quite High
Calcium channel 1 69.08 Quite High
Disease Link Frequency Relevance Heat
Stress 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At concentrations of 5 x 10(-6) and 10(-5) M, it produced a marked increase in CRF release; however, the simultaneous exposure of MBHs to each of these concentrations of NAL plus IL-2 caused a dose-dependent decrease in IL-2-induced CRF release, suggesting that beta-endorphin or other opioid peptides may play a role in IL-2-induced CRF release.
beta-endorphin Regulation (role) of CRF release associated with narcan and opioid
1) Confidence 0.12 Published 1995 Journal Neuroimmunomodulation Section Abstract Doc Link 8646567 Disease Relevance 0.13 Pain Relevance 0.60
beta-Endorphin modulates the inhibitory action of corticotropin-releasing factor on luteinizing hormone secretion.
beta-Endorphin Regulation (modulates) of corticotropin-releasing factor
2) Confidence 0.09 Published 1986 Journal NIDA Res. Monogr. Section Title Doc Link 2893271 Disease Relevance 0 Pain Relevance 0.36

General Comments

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