INT314980

Context Info Confidence 0.18 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

Lp1 (Mus musculus)

Pain Link Frequency Relevance Heat sodium channel 25 5.00 Action potential 14 5.00 addiction 6 5.00 potassium channel 3 5.00 Mexiletine 2 5.00 Pain 2 5.00 hyperexcitability 1 5.00 repetitive firing 1 5.00 local anesthetic 1 5.00 lidocaine 1 5.00

Disease Link Frequency Relevance Heat Channelopathies 8 50.00 Paralysis 8 48.64 Hypokalemic Periodic Paralysis 6 47.76 Hyperkalemia 8 5.64 Hypopituitarism 33 5.00 Myotonic Disorders 13 5.00 Disease 10 5.00 Congenital Myasthenic Syndromes 6 5.00 Muscle Disease 6 5.00 Hyperkalemic Periodic Paralysis 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Therefore, in the presence of a small depolarizing leak current, LP1 is shifted to the right and a paradoxical depolarization is more likely to occur even at normal [K+]o

Localization (shifted) of LP1

1) Confidence 0.18 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883924 Disease Relevance 0 Pain Relevance 0

General Comments

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