INT315004

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.85
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Psmc1) cytoplasm (Psmc1)
Anatomy Link Frequency
bridges 1
Psmc1 (Mus musculus)
Pain Link Frequency Relevance Heat
halothane 2 44.40 Quite Low
adenocard 2 20.32 Low Low
Neurotransmitter 14 5.00 Very Low Very Low Very Low
Glutamate 8 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Action potential 6 5.00 Very Low Very Low Very Low
long-term potentiation 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
amygdala 2 5.00 Very Low Very Low Very Low
Intracerebroventricular 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypokalemic Periodic Paralysis 58 89.76 High High
Familial Periodic Paralyses 2 76.24 Quite High
Malignant Hyperthermia 16 62.80 Quite High
Channelopathies 34 50.00 Quite Low
Adverse Drug Reaction 2 48.32 Quite Low
Contracture 2 21.76 Low Low
Hypercapnia 2 12.80 Low Low
Acidosis 2 9.68 Low Low
Rhabdomyolysis 2 5.92 Low Low
Disease 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
S3 helices are located close to the S4 helix in different models of voltage-gated cation channels [90] and help to stabilize the S4 helix.
Positive_regulation (stabilize) of S4
1) Confidence 0.10 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.42 Pain Relevance 0
Although the relative movements of the adjacent S1–S3 helices with respect to S4 are a matter of debate [90], the negative charges in these helices (including S3) were shown to form salt bridges with the S4 positive charges, and these interactions change dynamically upon gating-induced S4 movements (as shown, e.g., for a “sliding helix model” [90]).
Positive_regulation (induced) of S4 in bridges
2) Confidence 0.06 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.44 Pain Relevance 0

General Comments

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