INT315006

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.26
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
myotubes 4
muscle 2
Tmie (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 25 100.00 Very High Very High Very High
agonist 10 82.52 Quite High
anesthesia 1 47.64 Quite Low
adenocard 1 29.20 Quite Low
halothane 5 17.16 Low Low
Neurotransmitter 7 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Action potential 3 5.00 Very Low Very Low Very Low
tetrodotoxin 2 5.00 Very Low Very Low Very Low
long-term potentiation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 16 69.72 Quite High
Malignant Hyperthermia 38 68.08 Quite High
Hypokalemic Periodic Paralysis 29 67.52 Quite High
Channelopathies 17 50.00 Quite Low
Renal Failure 1 42.08 Quite Low
Myoglobinuria 1 40.56 Quite Low
Hyperkalemia 1 39.12 Quite Low
Rhabdomyolysis 1 36.60 Quite Low
Acidosis 1 34.48 Quite Low
Hypercapnia 1 33.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In R163C Het myotubes, there was a small hyperpolarizing shift in SR Ca2+ release and a slight reduction in maximal release ([?
Regulation (shift) of Localization (release) of SR in myotubes
1) Confidence 0.04 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888063 Disease Relevance 0.05 Pain Relevance 0.18
In R163C Hom myotubes, the voltage dependence of SR Ca2+ release shifted to a greater extent and maximal release was substantially reduced (Fig. 1 and Table I).
Regulation (dependence) of Localization (release) of SR in myotubes associated with addiction
2) Confidence 0.04 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888063 Disease Relevance 0.07 Pain Relevance 0.19
1 subunits (also termed dihydropyridine receptors, DHPRs, in muscle) mechanically activate RyR1 and elicit SR Ca2+ release.
Regulation (elicit) of Localization (release) of SR in muscle
3) Confidence 0.03 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.14 Pain Relevance 0

General Comments

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