INT315011

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Context Info
Confidence 0.57
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 4.47
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cacna1d) plasma membrane (Cacna1d) transmembrane transport (Cacna1d)
Anatomy Link Frequency
neurons 1
cerebellum 1
Cacna1d (Mus musculus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 9 78.76 Quite High
Neurotransmitter 63 76.24 Quite High
amygdala 9 64.08 Quite High
long-term potentiation 18 63.44 Quite High
Hippocampus 9 61.64 Quite High
Action potential 27 48.76 Quite Low
addiction 27 24.08 Low Low
Glutamate 36 11.56 Low Low
anesthesia 9 5.00 Very Low Very Low Very Low
adenocard 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Channelopathies 153 100.00 Very High Very High Very High
Syndrome 54 98.96 Very High Very High Very High
Dystonia 90 98.52 Very High Very High Very High
Disease 126 98.48 Very High Very High Very High
Malignant Hyperthermia 72 92.44 High High
Anxiety Disorder 18 92.00 High High
Ataxia 18 81.68 Quite High
Stress 18 76.44 Quite High
Absence Epilepsy 9 70.88 Quite High
Targeted Disruption 36 59.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Somehow, altered Cav2.1 channel signaling appears to activate pathways that enhance Cav1.2 (but not Cav1.3; [38]) LTCC expression.
Gene_expression (expression) of LTCC
1) Confidence 0.57 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.65 Pain Relevance 0.03
The finding that enhanced LTCC expression and most likely activity in Purkinje cells contributes to the paroxysmal dystonia of the tottering phenotype is in good agreement with the observation that dystonic episodes lead to neuronal activation in the cerebellum and its relay nuclei in these mice [9], and that the dystonic phenotype is absent in tottering mice lacking Purkinje cells [11].
Gene_expression (expression) of LTCC in cerebellum associated with dystonia
2) Confidence 0.57 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.62 Pain Relevance 0.03
Due to this special role, the question arises whether pathological changes in other (i.e., non-L-type) Ca2+ channel isoforms [14] can lead to secondary changes in LTCC expression and thereby allow them to contribute to disease-related processes.
Gene_expression (expression) of LTCC associated with disease
3) Confidence 0.57 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.67 Pain Relevance 0.07
This finding is surprising because LTCC expression in these neurons is very low, thus mediating only about 7% of the total Ca2+ channel current [21, 38].
Gene_expression (expression) of LTCC in neurons
4) Confidence 0.57 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.73 Pain Relevance 0.04
Cav1.3 channelopathies (CACNA1D gene)
Gene_expression (gene) of CACNA1D associated with channelopathies
5) Confidence 0.56 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.48 Pain Relevance 0
Cav1.3 channelopathies (CACNA1D gene)
Gene_expression (channelopathies) of CACNA1D associated with channelopathies
6) Confidence 0.56 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.48 Pain Relevance 0
Obviously, channelopathies in different LTCC ?
Gene_expression (different) of LTCC associated with channelopathies
7) Confidence 0.49 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.29 Pain Relevance 0
Transcripts for all four LTCC ?
Gene_expression (four) of LTCC
8) Confidence 0.49 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.26 Pain Relevance 0.12
Obviously, channelopathies in different LTCC ?
Gene_expression (channelopathies) of LTCC associated with channelopathies
9) Confidence 0.49 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.29 Pain Relevance 0

General Comments

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