INT315024

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.50
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cacna1f)
Anatomy Link Frequency
pore 1
Cacna1f (Mus musculus)
Cacna1f - I745T (1)
Pain Link Frequency Relevance Heat
addiction 12 99.92 Very High Very High Very High
Glutamate 16 67.92 Quite High
Neurotransmitter 28 62.40 Quite High
Action potential 12 5.00 Very Low Very Low Very Low
long-term potentiation 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
amygdala 4 5.00 Very Low Very Low Very Low
Intracerebroventricular 4 5.00 Very Low Very Low Very Low
halothane 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Channelopathies 68 95.60 Very High Very High Very High
Syndrome 24 93.96 High High
Calcification 4 59.20 Quite High
Congenital Anomalies 4 20.96 Low Low
Rod Or Cone Dystrophy 4 9.52 Low Low
Night Blindness 36 6.20 Low Low
Hypokalemic Periodic Paralysis 116 5.00 Very Low Very Low Very Low
Disease 56 5.00 Very Low Very Low Very Low
Dystonia 40 5.00 Very Low Very Low Very Low
Malignant Hyperthermia 32 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From the activation curve, an about 50-fold increase of Cav1.4 inward current can be predicted upon depolarization to -35 mV.
Positive_regulation (increase) of Cav1.4
1) Confidence 0.41 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0 Pain Relevance 0.03
Fig. 3Mutations in Ca2+ channel Cav1.4 ?
Positive_regulation (3Mutations) of Cav1.4
2) Confidence 0.41 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.27 Pain Relevance 0
Notably, they found that deletion of the C-terminal domain not only restored robust CDI but also induced a strong hyperpolarizing shift of the voltage dependence of Cav1.4 activation [67].
Positive_regulation (activation) of Cav1.4 associated with addiction
3) Confidence 0.38 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.06 Pain Relevance 0.08
The missense mutation I745T in the pore helix IIS6 produced a remarkable -30-mV shift in the voltage dependence of Cav1.4 channel activation as well as significantly slower inactivation kinetics when expressed in tsA-201 cells [31].
Positive_regulation (activation) of Cav1.4 (I745T) in pore associated with addiction
4) Confidence 0.38 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.17 Pain Relevance 0.05

General Comments

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