INT315028

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Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.86
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Cav2) mitochondrion organization (Cav2) intracellular (Cav2)
protein complex (Cav2) cytoplasm (Cav2) cytosol (Cav2)
Anatomy Link Frequency
pyramidal neurons 1
Cav2 (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 30 99.30 Very High Very High Very High
addiction 19 92.20 High High
Hippocampus 9 90.32 High High
Action potential 47 89.16 High High
Glutamate 18 75.00 Quite High
Calcium channel 28 73.80 Quite High
Glutamate receptor 13 61.48 Quite High
Neurotransmitter 11 60.88 Quite High
Neuronal excitability 6 46.00 Quite Low
antagonist 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Channelopathies 17 99.98 Very High Very High Very High
Disease 18 94.96 High High
Syndrome 6 87.76 High High
Night Blindness 9 86.12 High High
Malignant Hyperthermia 8 83.16 Quite High
Hypokalemic Periodic Paralysis 29 82.08 Quite High
Targeted Disruption 18 5.00 Very Low Very Low Very Low
Dystonia 10 5.00 Very Low Very Low Very Low
Epilepsy 2 5.00 Very Low Very Low Very Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that mGluRs may dramatically alter the firing of CA1 pyramidal neurons via a complex, activity-dependent modulation of Cav2.3 R-type channels that are activated during spiking at physiologically relevant rates and patterns.


Regulation (modulation) of Cav2 in pyramidal neurons associated with pyramidal cell
1) Confidence 0.43 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.50
The consequences of this Ca2+ release are unknown, but we postulate it is an essential step in the complex cascade of signal transduction events that ultimately result in modulation of the Cav2.3 subunits responsible for the medium ADP.
Regulation (modulation) of Cav2
2) Confidence 0.19 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.04
Studies in mice revealed that LTCCs indirectly also contribute to neurological symptoms in Ca2+ channelopathies affecting non-LTCCs, such as Cav2.1 ?
Regulation (affecting) of Cav2 associated with channelopathies
3) Confidence 0.10 Published 2010 Journal Pflugers Arch Section Abstract Doc Link PMC2883925 Disease Relevance 0.86 Pain Relevance 0

General Comments

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