INT315032

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Context Info
Confidence 0.27
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.20
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Cav1, Ryr1) plasma membrane (Cav1, Ryr1) endosome (Cav1)
transport (Ryr1) mitochondrion (Cav1) Golgi apparatus (Cav1)
Anatomy Link Frequency
skeletal muscle 1
Cav1 (Mus musculus)
Ryr1 (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 1 69.80 Quite High
long-term potentiation 2 69.16 Quite High
Hippocampus 1 67.36 Quite High
Neurotransmitter 7 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Action potential 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Intracerebroventricular 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 2 71.64 Quite High
Disease 14 64.80 Quite High
Channelopathies 17 60.88 Quite High
Night Blindness 9 40.48 Quite Low
Hypokalemic Periodic Paralysis 29 34.08 Quite Low
Hypotension 1 32.12 Quite Low
Malignant Hyperthermia 8 30.88 Quite Low
Dystonia 10 5.00 Very Low Very Low Very Low
Syndrome 6 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This seems to be accomplished through a close physical association of Cav1.1 channels in the T-tubular membrane and RyR1 in the junctional SR of the skeletal muscle triads [45].
Cav1 Binding (association) of RyR1 in skeletal muscle
1) Confidence 0.27 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.20 Pain Relevance 0.14

General Comments

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