INT315092

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.29
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
hippocampus 1
MIR34A (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 4 98.92 Very High Very High Very High
Glutamate receptor 3 71.28 Quite High
GABAergic 1 46.28 Quite Low
gABA 7 42.32 Quite Low
bDMF 16 38.48 Quite Low
Lamotrigine 23 5.00 Very Low Very Low Very Low
depression 11 5.00 Very Low Very Low Very Low
carbamazepine 9 5.00 Very Low Very Low Very Low
anticonvulsant 8 5.00 Very Low Very Low Very Low
Gabapentin 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 184 93.60 High High
Manic Depressive Disorder 125 84.32 Quite High
Colon Cancer 129 82.60 Quite High
Intellectual Impairment 1 77.08 Quite High
Carcinoma 3 76.08 Quite High
Death 19 74.32 Quite High
Neurodegenerative Disease 4 70.96 Quite High
Cancer 70 52.84 Quite High
Reprotox - General 1 30 49.04 Quite Low
Disease 25 41.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most intriguing finding was reported for miR-221 and miR-34a, two miRNAs previously shown to be regulated by lithium and VPA in rat hippocampus [158].
Regulation (regulated) of miR-34a in hippocampus associated with hippocampus
1) Confidence 0.26 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.32 Pain Relevance 0.09
Moreover, one particular deregulated microRNA miR-34a, which was up-regulated in response to overexpressed Par-4, was functionally characterized in greater detail.
Regulation (deregulated) of miR-34a
2) Confidence 0.11 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.45 Pain Relevance 0
Moreover, one particular deregulated microRNA miR-34a, which was up-regulated in response to overexpressed Par-4, was functionally characterized in greater detail.
Regulation (regulated) of miR-34a
3) Confidence 0.11 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.45 Pain Relevance 0
Lastly, siRNA-mediated knockdown of DROSHA in HT29 cells (thus bypassing Par-4 overexpression) was found to up-regulate miR-34a levels by more than 2-fold compared to scrambled control as defined by qRT-PCR (P < 0.05, unpaired t-test; n = 4 independent determinations).
Regulation (regulate) of miR-34a
4) Confidence 0.11 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.07 Pain Relevance 0

General Comments

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