INT31512

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Context Info
Confidence 0.65
First Reported 1986
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.43
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (FEM1B) nucleus (FEM1B) cytoplasm (FEM1B)
Anatomy Link Frequency
brain 1
FEM1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 1 97.78 Very High Very High Very High
Intracerebroventricular 1 95.28 Very High Very High Very High
Dynorphin 2 93.64 High High
opioid receptor 2 89.28 High High
antagonist 3 86.84 High High
Hippocampus 2 76.96 Quite High
Opioid 3 76.24 Quite High
narcan 3 72.32 Quite High
Endogenous opioid 1 25.00 Low Low
cytokine 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Hypertension 5 100.00 Very High Very High Very High
Sprains And Strains 3 60.24 Quite High
Neuroblastoma 2 25.00 Low Low
Glioma 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Synthetic rat-human corticotropin releasing-factor (CRF), in doses between 10(-12) M and 10(-8) M, significantly stimulates the release of immunoreactive beta-endorphin and dynorphin-A from rat hypothalamic slices superfused in vitro.
Gene_expression (Synthetic) of rat- associated with dynorphin
1) Confidence 0.65 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2893273 Disease Relevance 0 Pain Relevance 0.26
The inhibitory effects on HPA activity were observed after intraperitoneal (i.p.) injections of rHu-IFN-alpha 2A (10(3) U), rHu-IFN-alpha A/D (10(4) U), and of Rat-IFN-alpha (1 and 10 U).
Gene_expression (injections) of Rat-
2) Confidence 0.65 Published 1994 Journal Brain Behav. Immun. Section Abstract Doc Link 8003770 Disease Relevance 0 Pain Relevance 0.21
Previous studies in this laboratory have shown that dynorphins acting on hippocampal kappa opioid receptors in rat brain exert a restraining influence on arterial blood pressure and that a relative deficiency of their production in the spontaneously hypertensive rat (SHR) may be involved in SHR hypertension.
Gene_expression (production) of SHR) in brain associated with hypertension and kappa opioid receptor
3) Confidence 0.65 Published 2000 Journal Clin. Exp. Hypertens. Section Abstract Doc Link 10937841 Disease Relevance 0.43 Pain Relevance 0.13

General Comments

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