INT31513

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.29
First Reported 1982
Last Reported 2004
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 5.06
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Crh, POMC) extracellular space (Crh, POMC) extracellular region (Crh, POMC)
small molecule metabolic process (POMC) cell-cell signaling (POMC) response to stress (Crh)
Anatomy Link Frequency
plasma 1
pituitary 1
Crh (Rattus norvegicus)
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 2 100.00 Very High Very High Very High
Multiple sclerosis 10 99.12 Very High Very High Very High
depression 74 97.70 Very High Very High Very High
Enkephalin 5 97.50 Very High Very High Very High
Morphine 7 97.18 Very High Very High Very High
dexamethasone 12 95.68 Very High Very High Very High
Fibrositis 368 93.68 High High
Opioid 4 87.24 High High
narcan 3 85.28 High High
Neuritis 1 71.84 Quite High
Disease Link Frequency Relevance Heat
Demyelinating Disease 10 99.12 Very High Very High Very High
Cushing's Syndrome /

Hypercortisolism

2 98.36 Very High Very High Very High
Depression 74 97.70 Very High Very High Very High
Frailty 4 97.16 Very High Very High Very High
Fibromyalgia 368 93.68 High High
Stress 246 90.36 High High
Congenital Anomalies 60 85.52 High High
Optic Neuritis 1 71.84 Quite High
INFLAMMATION 7 71.68 Quite High
Experimental Autoimmune Encephalomyelitis 1 70.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite this hypercortisolism and in contrast to patients with depression who had similar elevations in plasma cortisol levels, patients with MS showed normal, rather than blunted, plasma ACTH responses to ovine CRH, suggesting that the pathophysiology of hypercortisolism in MS is different from that in depression.
CRH Regulation (responses) of ACTH in plasma associated with multiple sclerosis and depression
1) Confidence 0.29 Published 1994 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8077372 Disease Relevance 1.45 Pain Relevance 0.68
Regulation of hypothalamic beta-endorphin and dynorphin release by corticotropin-releasing factor (CRF).
corticotropin-releasing factor Regulation (Regulation) of beta-endorphin associated with dynorphin
2) Confidence 0.21 Published 1986 Journal NIDA Res. Monogr. Section Title Doc Link 2893273 Disease Relevance 0 Pain Relevance 0.31
The influence of morphine and enkephalins on the functional activity of the hypothalamo-pituitary-adrenocortical system in the rat was studied by investigating their effects on the secretion in vivo and in vitro of corticotrophin (ACTH) by the pituitary gland and corticotrophin-releasing factor (CRF) by the hypothalamus.
corticotrophin-releasing factor Spec (investigating) Regulation (effects) of ACTH in pituitary associated with enkephalin and morphine
3) Confidence 0.15 Published 1982 Journal Neuroendocrinology Section Abstract Doc Link 6290921 Disease Relevance 0.08 Pain Relevance 0.85
The ACTH response to exogenous CRH is a good indicator of the existing CRH 'tonus'.
CRH Regulation (response) of ACTH
4) Confidence 0.03 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416451 Disease Relevance 0.38 Pain Relevance 0.17
Even in children with a history of sexual abuse or other abuse the data are inconsistent, with both a decreased ACTH response to exogenous CRH [13] and an increased ACTH response to exogenous CRH [14] being reported.
CRH Regulation (response) of ACTH
5) Confidence 0.03 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416451 Disease Relevance 0.86 Pain Relevance 0.22
Dynamic testing shows an exaggerated ACTH response but a blunted cortisol response to ovine CRH [7,18,19], and possibly reflects a CRH deficiency state and secondary atrophy of the adrenals due to chronic understimulation by reduced ACTH levels.
CRH Regulation (response) of ACTH associated with frailty
6) Confidence 0.03 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416451 Disease Relevance 1.26 Pain Relevance 0.34
Even in children with a history of sexual abuse or other abuse the data are inconsistent, with both a decreased ACTH response to exogenous CRH [13] and an increased ACTH response to exogenous CRH [14] being reported.
CRH Regulation (response) of ACTH
7) Confidence 0.03 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416451 Disease Relevance 0.84 Pain Relevance 0.21

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox