INT315141

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Context Info
Confidence 0.36
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.39
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Bcl2l1) cytosol (Bcl2l1) mitochondrion (Bcl2l1)
growth (Bcl2l1) cytoskeleton (Bcl2l1) intracellular (Bcl2l1)
Bcl2l1 (Mus musculus)
Pain Link Frequency Relevance Heat
positron emission tomography 8 23.52 Low Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 100 100.00 Very High Very High Very High
Targeted Disruption 29 89.80 High High
Injury 2 89.52 High High
Death 12 88.12 High High
Cancer 39 85.96 High High
Huntington's Chorea 1 84.48 Quite High
Stomach Cancer 1 72.84 Quite High
Stress 11 70.12 Quite High
Breast Cancer 1 63.28 Quite High
Lung Cancer 27 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bcl-xL is a member of the Bcl-2 family that acts on the mitochondrial membrane to prevent release of caspase activators such as cytochrome-C [27].
Localization (release) of Bcl-xL
1) Confidence 0.36 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 1.20 Pain Relevance 0
Chemically damaged cells undergo a p53-dependent apoptotic pathway that involves upregulation of p53 transcripts such as the pro-apoptotic Bcl2 family members and p53 translocation to the mitochondria, resulting in neutralization of the anti-apoptotic members Bcl-xL and Bcl-2 [26].
Localization (translocation) of Bcl-xL associated with apoptosis
2) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 1.19 Pain Relevance 0

General Comments

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