INT315145

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.88
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Flt1) endosome (Flt1) Golgi apparatus (Flt1)
plasma membrane (Flt1) nucleus (Flt1) kinase activity (Flt1)
Anatomy Link Frequency
endothelial cells 1
A549 1
Flt1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 23 94.40 High High
positron emission tomography 16 35.28 Quite Low
Inflammation 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 11 91.48 High High
Cancer 109 86.48 High High
Pancreatic Ductal Carcinoma 5 82.36 Quite High
Injury 49 81.12 Quite High
Pancreatic Cancer 28 80.40 Quite High
Apoptosis 45 78.24 Quite High
Non-small-cell Lung Cancer 26 77.20 Quite High
Diabetes Mellitus 51 72.48 Quite High
Colon Cancer 4 68.44 Quite High
Stress 2 57.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although such an effect has not been shown in endothelial cells, one could assume that VEGFR1 phosphorylation blockade would have a direct antiangiogenic effect.
Phosphorylation (phosphorylation) of VEGFR1 in endothelial cells
1) Confidence 0.40 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 0.80 Pain Relevance 0
Interestingly, Olaussen et al. [32] have recently demonstrated that lapatinib inhibits VEGFR1 phosphorylation by >70% in A549 cells.
Phosphorylation (phosphorylation) of VEGFR1 in A549
2) Confidence 0.40 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 0.71 Pain Relevance 0
Furthermore, the authors showed expression of the high-affinity Flt-1 receptor in human SMCs and its phosphorylation upon VEGF-A treatment, suggesting its role in mediating VEGF-A action.
Phosphorylation (phosphorylation) of Flt-1 receptor
3) Confidence 0.27 Published 2010 Journal Genet Vaccines Ther Section Body Doc Link PMC2939607 Disease Relevance 0.40 Pain Relevance 0
Furthermore, production of VEGF and phosphorylation of VEGFR-1 were significantly reduced by MUC5AC down regulation.
Phosphorylation (phosphorylation) of VEGFR-1
4) Confidence 0.13 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2893453 Disease Relevance 0.97 Pain Relevance 0.09

General Comments

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