INT315163

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.83
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Erbb2, Akt1) signal transduction (Erbb2, Akt1) nucleus (Erbb2, Akt1)
plasma membrane (Erbb2, Akt1) kinase activity (Erbb2, Akt1) transport (Akt1)
Erbb2 (Mus musculus)
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
positron emission tomography 8 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 39 94.88 High High
Apoptosis 22 90.40 High High
Death 4 84.72 Quite High
Lung Cancer 27 75.00 Quite High
Non-small-cell Lung Cancer 13 59.08 Quite High
Advanced Or Metastatic Breast Cancer 2 55.04 Quite High
Immunotherapy Of Cancer 1 47.68 Quite Low
Metastasis 1 43.08 Quite Low
Solid Tumor 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also demonstrate that lapatinib altered EGFR/HER-2 signaling pathways reducing p-EGFR, p-HER-2, p-ERK1/2, p-AKT, c-Myc and PCNA levels.
HER-2 Negative_regulation (reducing) of AKT
1) Confidence 0.17 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2883966 Disease Relevance 0.83 Pain Relevance 0

General Comments

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